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Modifiable causes o...
Modifiable causes of premature death in middle-age in Western Europe : Results from the EPIC cohort study
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- Muller, David C. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Murphy, Neil (författare)
- Imperial College London
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization
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- Ferrari, Pietro (författare)
- International Agency for Research on Cancer, World Health Organization
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- Tsilidis, Konstantinos K. (författare)
- Imperial College London
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- Boutron-Ruault, Marie Christine (författare)
- Institut Gustave Roussy
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- Clavel, Francoise (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Dartois, Laureen (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Li, Kuanrong (författare)
- German Cancer Research Centre
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Weikert, Cornelia (författare)
- German Institute of Human Nutrition
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- Bergmann, Manuela (författare)
- German Institute of Human Nutrition
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Overvad, Kim (författare)
- Aarhus University
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- Redondo, M. Luisa (författare)
- Public Health Directorate
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- Agudo, Antonio (författare)
- Catalan Institute of Oncology,University Medical Center Utrecht
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- Molina-Portillo, Elena (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Altzibar, Jone M. (författare)
- Biodonostia Health Research Institute
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- Cirera, Lluís (författare)
- University of Murcia
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- Ardanaz, Eva (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Khaw, Kay Tee (författare)
- University of Cambridge
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- Wareham, Nicholas J. (författare)
- University of Cambridge
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- Key, Timothy J. (författare)
- University of Oxford
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- Travis, Ruth C. (författare)
- University of Oxford
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- Bamia, Christina (författare)
- National and Kapodistrian University of Athens
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- Orfanos, Philippos (författare)
- National and Kapodistrian University of Athens
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- Trichopoulou, Antonia (författare)
- National and Kapodistrian University of Athens
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Pala, Valeria (författare)
- Istituto Nazionale dei Tumori
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Vineis, Paolo (författare)
- Human Genetics Foundation (HuGeF)
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Bueno-de-Mesquita, H. Bas (författare)
- University of Malaya
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- Verschuren, W. M Monique (författare)
- University Medical Center Utrecht
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- Struijk, Ellen A. (författare)
- University Medical Center Utrecht
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- Peeters, Petra H. (författare)
- University Medical Center Utrecht
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Sund, Malin (författare)
- Umeå universitet,Umeå University,Kirurgi
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet
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- Skeie, Guri (författare)
- UiT The Arctic University of Norway, Tromsø
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- Lund, Eiliv (författare)
- UiT The Arctic University of Norway, Tromsø
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- Norat, Teresa (författare)
- Imperial College London
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- Gunter, Marc (författare)
- Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Brennan, Paul (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2016-06-14
- 2016
- Engelska.
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Ingår i: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 14:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death. Methods: We analysed data from 264,906 European adults from the EPIC prospective cohort study, aged between 40 and 70 years at the time of recruitment. Flexible parametric survival models were used to model risk of death conditional on risk factors, and survival functions and attributable fractions (AF) for deaths prior to age 70 years were calculated based on the fitted models. Results: We identified 11,930 deaths which occurred before the age of 70. The AF for premature mortality for smoking was 31 % (95 % confidence interval (CI), 31-32 %) and 14 % (95 % CI, 12-16 %) for poor diet. Important contributions were also observed for overweight and obesity measured by waist-hip ratio (10 %; 95 % CI, 8-12 %) and high blood pressure (9 %; 95 % CI, 7-11 %). AFs for physical inactivity and excessive alcohol intake were 7 % and 4 %, respectively. Collectively, the AF for all six risk factors was 57 % (95 % CI, 55-59 %), being 35 % (95 % CI, 32-37 %) among never smokers and 74 % (95 % CI, 73-75 %) among current smokers. Conclusions: While smoking remains the predominant risk factor for premature death in Europe, poor diet, overweight and obesity, hypertension, physical inactivity, and excessive alcohol consumption also contribute substantially. Any attempt to minimise premature deaths will ultimately require all six factors to be addressed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Absolute risk
- Attributable fraction
- Modifiable risk factors
- Mortality
- Premature death
- Premature death
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Muller, David C.
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Murphy, Neil
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Johansson, Matti ...
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Ferrari, Pietro
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Tsilidis, Konsta ...
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Boutron-Ruault, ...
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visa fler...
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Clavel, Francois ...
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Dartois, Laureen
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Li, Kuanrong
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Kaaks, Rudolf
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Weikert, Corneli ...
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Bergmann, Manuel ...
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Boeing, Heiner
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Tjønneland, Anne
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Overvad, Kim
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Redondo, M. Luis ...
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Agudo, Antonio
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Molina-Portillo, ...
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Altzibar, Jone M ...
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Cirera, Lluís
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Ardanaz, Eva
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Khaw, Kay Tee
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Wareham, Nichola ...
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Key, Timothy J.
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Travis, Ruth C.
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Bamia, Christina
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Orfanos, Philipp ...
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Trichopoulou, An ...
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Palli, Domenico
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Pala, Valeria
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Tumino, Rosario
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Vineis, Paolo
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Verschuren, W. M ...
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Struijk, Ellen A ...
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Peeters, Petra H ...
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Engström, Gunnar
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Melander, Olle
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Sund, Malin
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Weiderpass, Elis ...
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Skeie, Guri
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Lund, Eiliv
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Norat, Teresa
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Gunter, Marc
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Riboli, Elio
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Brennan, Paul
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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BMC Medicine
- Av lärosätet
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Lunds universitet
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Umeå universitet
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Karolinska Institutet