Sökning: (WFRF:(Wallace Paul)) srt2:(2005-2009) > (2009) > Six new loci associ...
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000 | 08427naa a2202053 4500 | |
001 | oai:lup.lub.lu.se:2491406b-cf62-451a-b8ad-df523798e528 | |
003 | SwePub | |
008 | 160401s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/13129912 URI |
024 | 7 | a https://doi.org/10.1038/ng.2872 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Willer, Cristen J.4 aut |
245 | 1 0 | a Six new loci associated with body mass index highlight a neuronal influence on body weight regulation |
264 | c 2008-12-14 | |
264 | 1 | b Springer Science and Business Media LLC,c 2009 |
520 | a Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
700 | 1 | a Speliotes, Elizabeth K.4 aut |
700 | 1 | a Loos, Ruth J. F.4 aut |
700 | 1 | a Li, Shengxu4 aut |
700 | 1 | a Lindgren, Cecilia M.4 aut |
700 | 1 | a Heid, Iris M.4 aut |
700 | 1 | a Berndt, Sonja I.4 aut |
700 | 1 | a Elliott, Amanda L.4 aut |
700 | 1 | a Jackson, Anne U.4 aut |
700 | 1 | a Lamina, Claudia4 aut |
700 | 1 | a Lettre, Guillaume4 aut |
700 | 1 | a Lim, Noha4 aut |
700 | 1 | a Lyon, Helen N.4 aut |
700 | 1 | a McCarroll, Steven A.4 aut |
700 | 1 | a Papadakis, Konstantinos4 aut |
700 | 1 | a Qi, Lu4 aut |
700 | 1 | a Randall, Joshua C.4 aut |
700 | 1 | a Roccasecca, Rosa Maria4 aut |
700 | 1 | a Sanna, Serena4 aut |
700 | 1 | a Scheet, Paul4 aut |
700 | 1 | a Weedon, Michael N.4 aut |
700 | 1 | a Wheeler, Eleanor4 aut |
700 | 1 | a Zhao, Jing Hua4 aut |
700 | 1 | a Jacobs, Leonie C.4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Timpson, Nicholas J.4 aut |
700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
700 | 1 | a Bennett, Amanda4 aut |
700 | 1 | a Bergman, Richard N.4 aut |
700 | 1 | a Bingham, Sheila A.4 aut |
700 | 1 | a Bonnycastle, Lori L.4 aut |
700 | 1 | a Brown, Morris4 aut |
700 | 1 | a Burtt, Noel L. P.4 aut |
700 | 1 | a Chines, Peter4 aut |
700 | 1 | a Coin, Lachlan4 aut |
700 | 1 | a Collins, Francis S.4 aut |
700 | 1 | a Connell, John M.4 aut |
700 | 1 | a Cooper, Cyrus4 aut |
700 | 1 | a Smith, George Davey4 aut |
700 | 1 | a Dennison, Elaine M.4 aut |
700 | 1 | a Deodhar, Parimal4 aut |
700 | 1 | a Elliott, Paul4 aut |
700 | 1 | a Erdos, Michael R.4 aut |
700 | 1 | a Estrada, Karol4 aut |
700 | 1 | a Evans, David M.4 aut |
700 | 1 | a Gianniny, Lauren4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Gillson, Christopher J.4 aut |
700 | 1 | a Guiducci, Candace4 aut |
700 | 1 | a Hackett, Rachel4 aut |
700 | 1 | a Hadley, David4 aut |
700 | 1 | a Hall, Alistair S.4 aut |
700 | 1 | a Havulinna, Aki S.4 aut |
700 | 1 | a Hebebrand, Johannes4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Isomaa, Bo4 aut |
700 | 1 | a Jacobs, Kevin B.4 aut |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Jousilahti, Pekka4 aut |
700 | 1 | a Jovanovic, Zorica4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Kuokkanen, Mikko4 aut |
700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Laitinen, Jaana4 aut |
700 | 1 | a Lakatta, Edward G.4 aut |
700 | 1 | a Luan, Jian'an4 aut |
700 | 1 | a Luben, Robert N.4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a McArdle, Wendy L.4 aut |
700 | 1 | a Meitinger, Thomas4 aut |
700 | 1 | a Mulas, Antonella4 aut |
700 | 1 | a Munroe, Patricia B.4 aut |
700 | 1 | a Narisu, Narisu4 aut |
700 | 1 | a Ness, Andrew R.4 aut |
700 | 1 | a Northstone, Kate4 aut |
700 | 1 | a O'Rahilly, Stephen4 aut |
700 | 1 | a Purmann, Carolin4 aut |
700 | 1 | a Rees, Matthew G.4 aut |
700 | 1 | a Ridderstråle, Martinu Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups4 aut0 (Swepub:lu)endo-mri |
700 | 1 | a Ring, Susan M.4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Ruokonen, Aimo4 aut |
700 | 1 | a Sandhu, Manjinder S.4 aut |
700 | 1 | a Saramies, Jouko4 aut |
700 | 1 | a Scott, Laura J.4 aut |
700 | 1 | a Scuteri, Angelo4 aut |
700 | 1 | a Silander, Kaisa4 aut |
700 | 1 | a Sims, Matthew A.4 aut |
700 | 1 | a Song, Kijoung4 aut |
700 | 1 | a Stephens, Jonathan4 aut |
700 | 1 | a Stevens, Suzanne4 aut |
700 | 1 | a Stringham, Heather M.4 aut |
700 | 1 | a Tung, Y. C. Loraine4 aut |
700 | 1 | a Valle, Timo T.4 aut |
700 | 1 | a Van Duijn, Cornelia M.4 aut |
700 | 1 | a Vimaleswaran, Karani S.4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Waeber, Gerard4 aut |
700 | 1 | a Wallace, Chris4 aut |
700 | 1 | a Watanabe, Richard M.4 aut |
700 | 1 | a Waterworth, Dawn M.4 aut |
700 | 1 | a Watkins, Nicholas4 aut |
700 | 1 | a Witteman, Jacqueline C. M.4 aut |
700 | 1 | a Zeggini, Eleftheria4 aut |
700 | 1 | a Zhai, Guangju4 aut |
700 | 1 | a Zillikens, M. Carola4 aut |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Caulfield, Mark J.4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Farooqi, I. Sadaf4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Guralnik, Jack M.4 aut |
700 | 1 | a Hattersley, Andrew T.4 aut |
700 | 1 | a Hu, Frank B.4 aut |
700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a Mooser, Vincent4 aut |
700 | 1 | a Ong, Ken K.4 aut |
700 | 1 | a Ouwehand, Willem H.4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Spector, Timothy D.4 aut |
700 | 1 | a Tuomi, Tiinamaija4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Uda, Manuela4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Deloukas, Panagiotis4 aut |
700 | 1 | a Frayling, Timothy M.4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Hayes, Richard B.4 aut |
700 | 1 | a Hunter, David J.4 aut |
700 | 1 | a Mohlke, Karen L.4 aut |
700 | 1 | a Peltonen, Leena4 aut |
700 | 1 | a Schlessinger, David4 aut |
700 | 1 | a Strachan, David P.4 aut |
700 | 1 | a Wichmann, H-Erich4 aut |
700 | 1 | a McCarthy, Mark I.4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Barroso, Ines4 aut |
700 | 1 | a Abecasis, Goncalo R.4 aut |
700 | 1 | a Hirschhorn, Joel N.4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 41:1, s. 25-34q 41:1<25-34x 1546-1718x 1061-4036 |
856 | 4 | u http://dx.doi.org/10.1038/ng.287y FULLTEXT |
856 | 4 | u https://cdr.lib.unc.edu/downloads/zp38wm65s |
856 | 4 8 | u https://lup.lub.lu.se/record/1312991 |
856 | 4 8 | u https://doi.org/10.1038/ng.287 |
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