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Risk Stratification...
Risk Stratification by Ambulatory Blood Pressure Monitoring Across JNC Classes of Conventional Blood Pressure
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Brguljan-Hitij, Jana (author)
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Thijs, Lutgarde (author)
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Li, Yan (author)
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Hansen, Tine W. (author)
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Boggia, Jose (author)
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Liu, Yan-Ping (author)
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Asayama, Kei (author)
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Wei, Fang-Fei (author)
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- Bjorklund-Bodegard, Kristina (author)
- Karolinska Institutet
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Gu, Yu-Mei (author)
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Ohkubo, Takayoshi (author)
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Jeppesen, Jorgen (author)
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Torp-Pedersen, Christian (author)
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Dolan, Eamon (author)
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Kuznetsova, Tatiana (author)
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Stolarz-Skrzypek, Katarzyna (author)
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Tikhonoff, Valerie (author)
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Malyutina, Sofia (author)
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Casiglia, Edoardo (author)
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Nikitin, Yuri (author)
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- Lind, Lars (author)
- Uppsala universitet,Geriatrik
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Sandoya, Edgardo (author)
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Kawecka-Jaszcz, Kalina (author)
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Filipovsky, Jan (author)
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Imai, Yutaka (author)
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Wang, Jiguang (author)
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O'Brien, Eoin (author)
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Staessen, Jan A. (author)
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(creator_code:org_t)
- 2014-02-26
- 2014
- English.
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In: American Journal of Hypertension. - : Oxford University Press (OUP). - 0895-7061 .- 1941-7225. ; 27:7, s. 956-965
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND Guidelines propose classification of conventional blood pressure (CBP) into normotension (<120/<80 mm Hg), prehypertension (120-139/80-89 mm Hg), and hypertension (>140/>90 mm Hg). METHODS To assess the potential differential contribution of ambulatory blood pressure (ABP) in predicting risk across CBP strata, we analyzed outcomes in 7,826 untreated people recruited from 11 populations. RESULTS During an 11.3-year period, 809 participants died (276 cardiovascular deaths) and 639, 383, and 225 experienced a cardiovascular, cardiac, or cerebrovascular event. Compared with normotension (n = 2,639), prehypertension (n = 3,076) carried higher risk (P <= 0.015) of cardiovascular (+ 41%) and cerebrovascular (+ 92%) endpoints; compared with hypertension (n = 2,111) prehypertension entailed lower risk (P <= 0.005) of total mortality (-14%) and cardiovascular mortality (-29%) and of cardiovascular (-34%), cardiac (-33%), or cerebrovascular (-47%) events. Multivariable-adjusted hazard ratios (HRs) for stroke associated with 24-hour and daytime diastolic ABP (+ 5 mm Hg) were higher (P <= 0.045) in normotension than in prehypertension and hypertension (1.98 vs. 1.19 vs. 1.28 and 1.73 vs. 1.09 vs. 1.24, respectively) with similar trends (0.03 <= P <= 0.11) for systolic ABP (+10 mm Hg). However, HRs for fatal endpoints and cardiac events associated with ABP did not differ significantly (P >= 0.13) across CBP categories. Of normotensive and prehypertensive participants, 7.5% and 29.3% had masked hypertension (daytime ABP >= 135/>= 85 mm Hg). Compared with true normotension (P <= 0.01), HRs for stroke were 3.02 in normotension and 2.97 in prehypertension associated with masked hypertension with no difference between the latter two conditions (P = 0.93). CONCLUSION ABP refines risk stratification in normotension and prehypertension mainly by enabling the diagnosis of masked hypertension.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- ambulatory blood pressure monitoring
- blood pressure
- hypertension
- masked hypertension
- population science
- prehypertension
- risk stratification
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brguljan-Hitij, ...
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Thijs, Lutgarde
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Li, Yan
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Hansen, Tine W.
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Boggia, Jose
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Liu, Yan-Ping
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show more...
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Asayama, Kei
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Wei, Fang-Fei
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Bjorklund-Bodega ...
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Gu, Yu-Mei
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Ohkubo, Takayosh ...
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Jeppesen, Jorgen
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Torp-Pedersen, C ...
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Dolan, Eamon
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Kuznetsova, Tati ...
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Stolarz-Skrzypek ...
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Tikhonoff, Valer ...
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Malyutina, Sofia
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Casiglia, Edoard ...
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Nikitin, Yuri
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Lind, Lars
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Sandoya, Edgardo
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Kawecka-Jaszcz, ...
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Filipovsky, Jan
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Imai, Yutaka
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Wang, Jiguang
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O'Brien, Eoin
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Staessen, Jan A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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American Journal ...
- By the university
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Uppsala University
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Karolinska Institutet