Sökning: onr:"swepub:oai:lup.lub.lu.se:f7e9b176-5895-4e5b-b3dd-16e8d8a6a6f7" >
Lifetime alcohol in...
Abstract
Ämnesord
Stäng
- Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity =.02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- cardia cancer
- EPIC
- lifetime alcohol intake
- MCCS
- noncardia cancer
- stomach cancer
- EPIC
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jayasekara, Hari ...
-
MacInnis, Robert ...
-
Lujan-Barroso, L ...
-
Mayen-Chacon, An ...
-
Cross, Amanda J.
-
Wallner, Bengt, ...
-
visa fler...
-
Palli, Domenico
-
Ricceri, Fulvio
-
Pala, Valeria
-
Panico, Salvator ...
-
Tumino, Rosario
-
Kühn, Tilman
-
Kaaks, Rudolf
-
Tsilidis, Kostas
-
Sánchez, Maria J ...
-
Amiano, Pilar
-
Ardanaz, Eva
-
Chirlaque López, ...
-
Merino, Susana
-
Rothwell, Joseph ...
-
Boutron-Ruault, ...
-
Severi, Gianluca
-
Sternby, Hanna
-
Sonestedt, Emily
-
Bueno-de-Mesquit ...
-
Boeing, Heiner
-
Travis, Ruth
-
Sandanger, Torkj ...
-
Trichopoulou, An ...
-
Karakatsani, Ann ...
-
Peppa, Eleni
-
Tjønneland, Anne
-
Yang, Yi
-
Hodge, Allison M ...
-
Mitchell, Hazel
-
Haydon, Andrew
-
Room, Robin
-
Hopper, John L.
-
Weiderpass, Elis ...
-
Gunter, Marc J.
-
Riboli, Elio
-
Giles, Graham G.
-
Milne, Roger L.
-
Agudo, Antonio
-
English, Dallas ...
-
Ferrari, Pietro
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kirurgi
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Lunds universitet
-
Umeå universitet
-
Stockholms universitet