Single-step manufacturing of femtoliter microwell arrays in a novel surface energy mimicking polymer

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Fältnamn	Indikatorer	Metadata
000		04453naa a2200721 4500
001		oai:DiVA.org:kth-159580
003		SwePub
008		150204s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1595802 URI
024	7	a https://doi.org/10.1109/TRANSDUCERS.2015.71809732 DOI
040		a (SwePub)kth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a kon2 swepub-publicationtype
100	1	a Decrop, Deborahu KU Leuven, Belgium4 aut
245	1 0	a Single-step manufacturing of femtoliter microwell arrays in a novel surface energy mimicking polymer
264	1	b IEEE,c 2015
338		a print2 rdacarrier
500		a QC 20150210
520		a We report a novel polymer material formulation and stamp-molding technique that enable rapid single-step manufacturing of hydrophilic-in-hydrophobic microwell arrays. We developed a modified thiol-ene-epoxy polymer (mOSTE+) formulation that mimics the surface energy of its mold during polymerization. The polymer inherits the surface energy from the mold through molecular self-assembly, in which functional monomers self-assemble at the interface between the liquid prepolymer and the mold surface. Combining this novel mOSTE+ material with a stamp-molding process leads to simultaneous surface energy mimicking and micro-structuring. This method was used to manufacture microwells with hydrophilic bottom and hydrophobic sidewall, depressed in a surrounding hydrophobic surface. The microwell arrays were successfully tested for the self-assembly of 62’000 femtoliter-droplets. Such femtoliter droplet arrays are useful for, e.g., digital ELISA and single cell/molecule analysis applications.
650	7	a TEKNIK OCH TEKNOLOGIERx Nanoteknik0 (SwePub)2102 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Nano-technology0 (SwePub)2102 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Elektroteknik och elektronikx Annan elektroteknik och elektronik0 (SwePub)202992 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Electrical Engineering, Electronic Engineering, Information Engineeringx Other Electrical Engineering, Electronic Engineering, Information Engineering0 (SwePub)202992 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Materialteknikx Textil-, gummi- och polymermaterial0 (SwePub)205042 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Materials Engineeringx Textile, Rubber and Polymeric Materials0 (SwePub)205042 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Medicinsk laboratorie- och mätteknik0 (SwePub)206012 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Medical Laboratory and Measurements Technologies0 (SwePub)206012 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Kemiteknikx Polymerteknologi0 (SwePub)204032 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Chemical Engineeringx Polymer Technologies0 (SwePub)204032 hsv//eng
653		a OSTE
653		a microarray
653		a bioassay
653		a biosensor
653		a diagnostics
653		a lab-on-chip
653		a loc
653		a microfluidics
653		a OSTEmer
653		a surface modification
653		a microwell
653		a microwell array
653		a Teknisk materialvetenskap
653		a Materials Science and Engineering
653		a Electrical Engineering
653		a Elektro- och systemteknik
653		a Bioteknologi
653		a Biotechnology
653		a Fiber- och polymervetenskap
653		a Fibre and Polymer Science
653		a Medical Technology
653		a Medicinsk teknologi
700	1	a Pardon, Gaspard,d 1983-u KTH,Mikro- och nanosystemteknik4 aut0 (Swepub:kth)u18xx490
700	1	a Kokalj, Tadeju KU Leuven, Belgium4 aut
700	1	a Robert, Puersu KU Leuven, Belgium4 aut
700	1	a Haraldsson, Tommyu KTH,Mikro- och nanosystemteknik4 aut0 (Swepub:kth)u1ohdrr6
700	1	a Lammertyn, Jeroenu KU Leuven, Belgium4 aut
700	1	a van der Wijngaart, Wouteru KTH,Mikro- och nanosystemteknik4 aut0 (Swepub:kth)u1wdbont
710	2	a KU Leuven, Belgiumb Mikro- och nanosystemteknik4 org
773	0	t 18th International Conference on Solid-State Sensors, Actuators and Microsystems (IEEE TRANSDUCER 2015)d : IEEE
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-159580
856	4 8	u https://doi.org/10.1109/TRANSDUCERS.2015.7180973

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ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Nano technology

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ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Materials Engine ...; and Textile Rubber a ...

ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Medical Engineer ...; and Medical Laborato ...

ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Chemical Enginee ...; and Polymer Technolo ...

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By the university: Royal Institute of Technology

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