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Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA(1c) and other predictors of increasing BMISDS

Birkebaek, N. H. (author)
Aarhus Univ, Denmark
Kahlert, J. (author)
Aarhus Univ Hosp, Denmark
Bjarnason, R. (author)
Landspitali Univ Hosp, Iceland; Univ Iceland, Iceland
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Drivvoll, A. K. (author)
Oslo Univ Hosp, Norway
Johansen, A. (author)
Rigshosp, Denmark
Konradsdottir, E. (author)
Landspitali Univ Hosp, Iceland; Univ Iceland, Iceland
Pundziute-Lycka, A. (author)
Queen Silvia Childrens Hosp, Sweden
Samuelsson, Ulf (author)
Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
Skrivarhaug, T. (author)
Oslo Univ Hosp, Norway
Svensson, J. (author)
Univ Copenhagen, Denmark
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 (creator_code:org_t)
2018-05-31
2018
English.
In: Pediatric Diabetes. - : WILEY. - 1399-543X .- 1399-5448. ; 19:7, s. 1198-1205
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: Intensified insulin therapy may increase body weight and cause obesity. This study compared body mass index standard deviation score (BMISDS) and obesity rate in children with type 1 diabetes (T1D) in Denmark, Iceland, Norway and Sweden, and uncovered predictors for increasing BMISDS. Methods: Data registered in the Nordic national childhood diabetes databases during the period 2008-2012 on children below 15 years with T1D for more than 3 months were compiled, including information on gender, age, diabetes duration, hemoglobin A(1c) (HbA(1c)), insulin dose, severe hypoglycemia (SH), treatment modality, height and weight. The Swedish reference chart for BMI was used for calculating BMISDS. Results: Totally, 11025 children (48% females) (30994 registrations) were included. Medians by the last recorded examination were: age, 13.5 years; diabetes duration, 4.3 years; HbA(1c), 7.9% (63 mmol/mol); insulin dose, 0.8 IU/kg/d and BMISDS, 0.70. Obesity rate was 18.5%. Adjusted mean BMISDS (BMISDS adj) was inversely related to HbA(1c) and directly to diabetes duration. Higher BMISDS adj was found in those with an insulin dose above 0.6 IU/kg/d, and in girls above 10 years. Pump users had higher BMISDS adj than pen users, and patients with registered SH had higher BMISDS adj than patients without SH (both P amp;lt; .001). Conclusion: Obesity rate in children with T1D in the Nordic countries is high, however, with country differences. Low HbA(1c), long diabetes duration, higher insulin dose, pump treatment and experiencing a SH predicted higher BMISDS. Diabetes caregivers should balance the risk of obesity and the benefit of a very low HbA(1c).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

BMISDS; HbA(1c); insulin therapy modality; Nordic countries; obesity risk factors

Publication and Content Type

ref (subject category)
art (subject category)

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