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Sökning: L773:1531 2267 OR L773:1094 8341 > (2015-2019) > Comparative transcr...

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FältnamnIndikatorerMetadata
00007317naa a2200757 4500
001oai:gup.ub.gu.se/257348
003SwePub
008240528s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:136391152
009oai:DiVA.org:his-14112
0247 a https://gup.ub.gu.se/publication/2573482 URI
0247 a https://doi.org/10.1152/physiolgenomics.00007.20172 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1363911522 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-141122 URI
040 a (SwePub)gud (SwePub)kid (SwePub)his
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ghosheh, Nidalu Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Forskningscentrum för Systembiologi,Institutionen för biovetenskap,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Bioinformatik, Bioinformatics4 aut0 (Swepub:his)ghon
2451 0a Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue
264 1b American Physiological Society,c 2017
500 a CC BY 4.0
520 a Hepatocytes derived from human pluripotent stem cells (hPSC-HEP) have the potential to replace presently used hepatocyte sources applied in liver disease treatment and models of drug discovery and development. Established hepatocyte differentiation protocols are effective and generate hepatocytes, which recapitulate some key features of their in vivo counterparts. However, generating mature hPSC-HEP remains a challenge. In this study, we applied transcriptomics to investigate the progress of in vitro hepatic differentiation of hPSCs at the developmental stages, definitive endoderm, hepatoblasts, early hPSC-HEP, and mature hPSC-HEP, to identify functional targets that enhance efficient hepatocyte differentiation. Using functional annotation, pathway and protein interaction network analyses, we observed the grouping of differentially expressed genes in specific clusters representing typical developmental stages of hepatic differentiation. In addition, we identified hub proteins and modules that were involved in the cell cycle process at early differentiation stages. We also identified hub proteins that differed in expression levels between hPSC-HEP and the liver tissue controls. Moreover, we identified a module of genes that were expressed at higher levels in the liver tissue samples than in the hPSC-HEP. Considering that hub proteins and modules generally are essential and have important roles in the protein-protein interactions, further investigation of these genes and their regulators may contribute to a better understanding of the differentiation process. This may suggest novel target pathways and molecules for improvement of hPSC-HEP functionality, having the potential to finally bring this technology to a wider use.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
653 a human pluripotent stem cell
653 a stem cell-derived hepatocytes
653 a liver tissue
653 a differentiation
653 a HEPATOCYTE-LIKE CELLS
653 a GENE-EXPRESSION
653 a BIOLOGICAL NETWORKS
653 a MODELS
653 a METABOLISM
653 a CHALLENGES
653 a PATHWAY
653 a INJURY
653 a LEVEL
653 a FETAL
653 a human pluripotent stem cell
653 a Bioinformatik
653 a INF501 Integration of -omics Data
653 a INF502 Biomarkers
7001 a Kuppers-Munther, B.u Takara Bio Europe Aktiebolaget, Gothenburg, Sweden4 aut
7001 a Asplund, A.u Takara Bio Europe Aktiebolaget, Gothenburg, Sweden4 aut
7001 a Edsbagge, J.u Takara Bio Europe Aktiebolaget, Gothenburg, Sweden4 aut
7001 a Ulfenborg, Benjaminu Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Bioinformatik, Bioinformatics4 aut0 (Swepub:his)ulfb
7001 a Andersson, T. B.u Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden / Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Bjorquist, P.u NovaHep Aktiebolaget, Gothenburg, Sweden4 aut
7001 a Andersson, C. X.u Takara Bio Europe Aktiebolaget, Gothenburg, Sweden4 aut
7001 a Carén, Helena,d 1979u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,Sahlgrenska Cancer Center, Department of Pathology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xcareh
7001 a Simonsson, Stina,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xsimst
7001 a Sartipy, Peteru Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,AstraZeneca Research and Development, Global Medicines Development Cardiovascular and Metabolic Diseases Global Medicines Development Unit, Mölndal, Sweden,Bioinformatik, Bioinformatics4 aut0 (Swepub:his)sarp
7001 a Synnergren, Janeu Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Bioinformatik, Bioinformatics4 aut0 (Swepub:his)synj
7102 a Göteborgs universitetb Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin4 org
7730 t Physiological Genomicsd : American Physiological Societyg 49:8, s. 430-446q 49:8<430-446x 1094-8341x 1531-2267
8564 u https://www.physiology.org/doi/pdf/10.1152/physiolgenomics.00007.2017
8564 u https://doi.org/10.1152/physiolgenomics.00007.2017y Fulltext
8564 u https://his.diva-portal.org/smash/get/diva2:1141232/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/257348
8564 8u https://doi.org/10.1152/physiolgenomics.00007.2017
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:136391152
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14112

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