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Worse survival for ...
Worse survival for TP53 (p53)-mutated breast cancer patients receiving adjuvant CMF
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- Andersson, J. (author)
- Karolinska Institutet
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- Larsson, Lars, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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Klaar, S. (author)
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- Holmberg, Lars (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi,Gastrointestinal Surgery
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Nilsson, J. (author)
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Inganas, Mats (author)
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Carlsson, Göran, 1951 (author)
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Ohd, J. (author)
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- Rudenstam, Carl-Magnus, 1930 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna,Institute of Surgical Sciences
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- Gustavsson, Bengt, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Bergh, Jonas, 1954 (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Ann Oncol. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 16:5, s. 743-8
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: TP53 has been described as a prognostic factor in many malignancies, including breast cancer. Whether it also might be a predictive factor with reference to chemo- and endocrine therapy is more controversial. PATIENTS AND METHODS: We investigated relapse-free (RFS), breast cancer-corrected (BCCS) and overall survival (OS) related to TP53 status in node-positive breast cancer patients that had received polychemotherapy [cyclophosphamide, methotrexate, 5-fluorouracil (CMF)] and/or endocrine therapy (tamoxifen). Sequence analyses of the whole TP53 coding region was performed in 376 patients operated on for primary breast cancer with axillary lymph node metastases between 1984 and 1989 (median follow-up time 84 months). RESULTS: TP53 mutations were found in 105 patients (28%). We found 90 (82%) of the 110 mutations in the more frequently analysed exons 5-8, while the other 20 (18%) were located in exons 3-4 and 9-10, respectively. Univariate analyses showed TP53 to be a significant prognostic factor with regard to RFS, BCCS and OS in patients who received adjuvant CMF. CONCLUSIONS: TP53 mutations might induce resistance to certain modalities of breast cancer therapy. Sequence-determined TP53 mutation was of negative prognostic value in the total patient population and in the CMF treated patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Adult
- Aged
- Aged
- 80 and over
- Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
- Breast Neoplasms/drug therapy/*genetics/*mortality/pathology
- Chemotherapy
- Adjuvant
- Cisplatin/therapeutic use
- Cohort Studies
- Female
- Fluorouracil/therapeutic use
- Gene Expression Regulation
- Neoplastic
- Genes
- p53/*genetics
- Genetic Markers/genetics
- Humans
- Methotrexate/therapeutic use
- Middle Aged
- Mutation
- Neoplasm Staging
- Neoplasms
- Hormone-Dependent/drug therapy/*genetics/*mortality/pathology
- Polymerase Chain Reaction
- Probability
- Prognosis
- Retrospective Studies
- Risk Assessment
- Sensitivity and Specificity
- Survival Analysis
- Tamoxifen/therapeutic use
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ann Oncol
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To the university's database
- By the author/editor
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Andersson, J.
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Larsson, Lars, 1 ...
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Klaar, S.
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Holmberg, Lars
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Nilsson, J.
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Inganas, Mats
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Carlsson, Göran, ...
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Ohd, J.
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Rudenstam, Carl- ...
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Gustavsson, Beng ...
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Bergh, Jonas, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Ann Oncol
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet