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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005540naa a2200469 4500
001oai:DiVA.org:uu-274271
003SwePub
008160120s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2742712 URI
0247 a https://doi.org/10.1007/s00259-015-3156-92 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Adamczuk, Katarzynau Katholieke Univ Leuven, Lab Cognit Neurol, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Leuven Inst Neurosci & Dis, Alzheimer Res Ctr, B-3000 Leuven, Belgium.4 aut
2451 0a Amyloid imaging in cognitively normal older adults :b comparison between F-18-flutemetamol and C-11-Pittsburgh compound B
264 c 2015-08-12
264 1b Springer Science and Business Media LLC,c 2016
338 a print2 rdacarrier
520 a Purpose Preclinical, or asymptomatic, Alzheimer's disease (AD) refers to the presence of positive AD biomarkers in the absence of cognitive deficits. This research concept is being applied to define target populations for clinical drug development. In a prospective community-recruited cohort of cognitively intact older adults, we compared two amyloid imaging markers within subjects: F-18-flutemetamol and C-11-Pittsburgh compound B (PIB). Methods In 32 community-recruited cognitively intact older adults aged between 65 and 80 years, we determined the concordance between binary classification based on F-18-flutemetamol versus C-11-PIB according to semiquantitative assessment (standardized uptake value ratio in composite cortical volume, SUVRcomp) and, alternatively, according to visual reads. We also determined the correlation between F-18-flutemetamol and C-11-PIB SUVR and evaluated how this was affected by the reference region chosen (cerebellar grey matter versus pons) and the use of partial volume correction (PVC) in this population. Results Binary classification based on semiquantitative assessment was concordant between F-18-flutemetamol and C-11-PIB in 94 % of cases. Concordance of blinded binary visual reads between tracers was 84 %. The Spearman correlation between F-18-flutemetamol and C-11-PIB SUVRcomp with cerebellar grey matter as reference region was 0.84, with a slope of 0.98. Correlations in neocortical regions were significantly lower with the pons as reference region. PVC improved the correlation in striatum and medial temporal cortex. Conclusion For the definition of preclinical AD based on F-18-flutemetamol, concordance with C-11-PIB was highest using semiquantitative assessment with cerebellar grey matter as reference region.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653 a Amyloid PET
653 a Biomarker
653 a Alzheimer's disease
653 a Preclinical AD
7001 a Schaeverbeke, Jolienu Katholieke Univ Leuven, Lab Cognit Neurol, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Leuven Inst Neurosci & Dis, Alzheimer Res Ctr, B-3000 Leuven, Belgium.4 aut
7001 a Nelissen, Natalieu Katholieke Univ Leuven, Lab Cognit Neurol, B-3000 Leuven, Belgium.;Univ Oxford, Dept Psychiat, Oxford OX3 7JX, England.4 aut
7001 a Neyens, Veerleu Katholieke Univ Leuven, Lab Cognit Neurol, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Leuven Inst Neurosci & Dis, Alzheimer Res Ctr, B-3000 Leuven, Belgium.4 aut
7001 a Vandenbulcke, Mathieuu Univ Hosp Leuven, Dept Old Age Psychiat, B-3000 Leuven, Belgium.4 aut
7001 a Goffin, Karolienu Katholieke Univ Leuven, Nucl Med & Mol Imaging Dept, B-3000 Leuven, Belgium.;Univ Hosp Leuven, B-3000 Leuven, Belgium.4 aut
7001 a Lilja, Johanu Uppsala universitet,Radiologi,GE Healthcare, S-75323 Uppsala, Sweden.4 aut0 (Swepub:uu)johli248
7001 a Hilven, Kellyu Katholieke Univ Leuven, Lab Neuroimmunol, B-3000 Leuven, Belgium.4 aut
7001 a Dupont, Patricku Katholieke Univ Leuven, Lab Cognit Neurol, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Leuven Inst Neurosci & Dis, Alzheimer Res Ctr, B-3000 Leuven, Belgium.4 aut
7001 a Van Laere, Koenu Katholieke Univ Leuven, Leuven Inst Neurosci & Dis, Alzheimer Res Ctr, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Nucl Med & Mol Imaging Dept, B-3000 Leuven, Belgium.;Univ Hosp Leuven, B-3000 Leuven, Belgium.4 aut
7001 a Vandenberghe, Riku Katholieke Univ Leuven, Lab Cognit Neurol, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Leuven Inst Neurosci & Dis, Alzheimer Res Ctr, B-3000 Leuven, Belgium.;Univ Hosp Leuven, Dept Neurol, B-3000 Leuven, Belgium.4 aut
7102 a Katholieke Univ Leuven, Lab Cognit Neurol, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Leuven Inst Neurosci & Dis, Alzheimer Res Ctr, B-3000 Leuven, Belgium.b Katholieke Univ Leuven, Lab Cognit Neurol, B-3000 Leuven, Belgium.;Univ Oxford, Dept Psychiat, Oxford OX3 7JX, England.4 org
7730 t European Journal of Nuclear Medicine and Molecular Imagingd : Springer Science and Business Media LLCg 43:1, s. 142-151q 43:1<142-151x 1619-7070x 1619-7089
8564 u https://lirias.kuleuven.be/bitstream/123456789/514167/1/Flute_PIB_10072015_Lirias.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-274271
8564 8u https://doi.org/10.1007/s00259-015-3156-9

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