L773:1791 7530 OR L773:0250 7005
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A study of serum biomarkers associated with relapse of cervical cancer
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- Bohr Mordhorst, Louise, 1958- (author)
- Region Örebro län
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- Sorbe, Bengt (author)
- Region Örebro län
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- Ahlin, Cecilia (author)
- Department of Oncology, Örebro University Hospital, Örebro, Sweden
- (creator_code:org_t)
- 2012
- 2012
- English.
- In: Anticancer Research. - 0250-7005 .- 1791-7530. ; 32:11, s. 4913-22
- Journal article (peer-reviewed)
Abstract
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- BACKGROUND/AIM: To discover candidate protein biomarkers in the serum of patients with cervical cancer that differentiate between patients with relapse from those who are tumor-free after primary treatment with (platinum-based chemo-) radiation.PATIENTS AND METHODS: Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) with cation exchange (CM10) and hydrophobic/reverse-phase (H50) was used to examine 44 serum samples from patients with advanced cervical cancer, primarily treated with (platinum-based chemo-) radiation.RESULTS: Ten candidate biomarkers were identified in the serum of 34 patients. Six candidate markers were elevated in patients with no relapse and four were elevated in patients with relapse [p=0.007-0.11; area under the curve (AUC)=0.70-0.75]. Masses of candidate biomarkers ranged from 2,022 to 116,165 Da.CONCLUSION: Patients with relapse from primary advanced cervical cancer exhibit different serum protein expression profiles from those with no relapse.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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