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Holster, S.Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden,Nutrition-Gut-Brain Interactions Research Centre
(författare)
Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Wageningen Academic Publishers,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-88420
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88420URI
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https://doi.org/10.3920/BM2020.0010DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies:European Society of Clinical Nutrition and Metabolism (ESPEN) Netherlands Organization for Scientific Research (NWO)
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Faecal microbiota transfer (FMT) consists of the infusion of donor faecal material into the intestine of a patient with the aim to restore a disturbed gut microbiota. In this study, it was investigated whether FMT has an effect on faecal microbial composition, its functional capacity, faecal metabolite profiles and their interactions in 16 irritable bowel syndrome (IBS) patients. Faecal samples from eight different time points before and until six months after allogenic FMT (faecal material from a healthy donor) as well as autologous FMT (own faecal material) were analysed by 16S RNA gene amplicon sequencing and gas chromatography coupled to mass spectrometry (GS-MS). The results showed that the allogenic FMT resulted in alterations in the microbial composition that were detectable up to six months, whereas after autologous FMT this was not the case. Similar results were found for the functional profiles, which were predicted from the phylogenetic sequencing data. While both allogenic FMT as well as autologous FMT did not have an effect on the faecal metabolites measured in this study, correlations between the microbial composition and the metabolites showed that the microbe-metabolite interactions seemed to be disrupted after allogenic FMT compared to autologous FMT. This shows that FMT can lead to altered interactions between the gut microbiota and its metabolites in IBS patients. Further research should investigate if and how this affects efficacy of FMT treatments.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Repsilber, Dirk,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)drr
(författare)
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Geng, D.Faculty of Business, Science and Engineering, School of Science and Technology, Örebro University, Örebro, Sweden,Man-Technology-Environmental Research Centre
(författare)
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Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environmental Research Centre(Swepub:oru)tihn
(författare)
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Salonen, A.Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland
(författare)
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Lindqvist, Carl Mårten,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)melt
(författare)
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Rajan, Sukithar K,1978-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centr(Swepub:oru)srrn
(författare)
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de Vos, W. M.Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Laboratory of Microbiology, Wageningen University and Research Centre, Wageningen, the Netherlands
(författare)
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Brummer, Robert Jan,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)rnbr
(författare)
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König, Julia,1983-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)jkg
(författare)
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Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, SwedenNutrition-Gut-Brain Interactions Research Centre
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Beneficial Microbes: Wageningen Academic Publishers12:1, s. 17-301876-28831876-2891
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Holster, S.
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Repsilber, Dirk, ...
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Geng, D.
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Hyötyläinen, Tuu ...
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Salonen, A.
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Lindqvist, Carl ...
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Rajan, Sukithar ...
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de Vos, W. M.
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Brummer, Robert ...
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König, Julia, 19 ...
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