L773:2312 0541
Sökning: L773:2312 0541 > (2018) > Low plasma stem cel...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04056naa a2200313 4500 | |
| 001 | oai:lup.lub.lu.se:850a9d98-57af-4b2c-a472-c9151a6f249a | |
| 003 | SwePub | |
| 008 | 181206s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/850a9d98-57af-4b2c-a472-c9151a6f249a2 URI |
| 024 | 7 | a https://doi.org/10.1183/23120541.00035-20182 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Bouzina, Habibu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)ha5126bo |
| 245 | 1 0 | a Low plasma stem cell factor combined with high transforming growth factor-α identifies high-risk patients in pulmonary arterial hypertension |
| 264 | c 2018-11-12 | |
| 264 | 1 | b European Respiratory Society (ERS),c 2018 |
| 520 | a In pulmonary arterial hypertension (PAH), severe vasoconstriction and remodelling of small pulmonary arteries result in high mortality. Receptor tyrosine kinases and their ligands, such as transforming growth factor (TGF)-α, modulate proliferation in PAH. Although the receptor tyrosine kinase c-Kit has been shown to be overexpressed in PAH, the expression and role of its ligand stem cell factor (SCF) remain unknown. However, low plasma SCF levels are known to be linked to higher cardiovascular mortality risk. Using proximity extension assays, we measured SCF and TGF-α in venous plasma from treatment-naïve PAH patients and healthy controls. Patients were stratified into risk classes based on PAH guidelines. Plasma SCF was decreased (p=0.013) and TGF-α was increased (p<0.0001) in PAH patients compared to controls. SCF correlated to pulmonary vascular resistance (r=-0.66, p<0.0001), cardiac index (r=0.66, p<0.0001), venous oxygen saturation (r=0.47, p<0.0008), mean right atrial pressure (r=-0.44, p<0.002) and N-terminal pro-brain natriuretic protein (r=-0.39, p<0.006). SCF was lower in "high-risk" compared to "intermediate-risk" (p=0.0015) or "low-risk" (p=0.0009) PAH patients. SCF and TGF-α levels combined (SCF/TGF-α) resulted in 85.7% sensitivity and 81.5% specificity for detecting high-risk patients (p<0.0001). Finally, REVEAL (Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management) risk scores in PAH patients correlated to SCF/TGF-α levels (r=-0.50, p=0.0003). In conclusion, low plasma SCF combined with high TGF-α identifies high-risk PAH patients at baseline. Lower circulating SCF levels, which are associated with worse haemodynamics, may be related to the c-Kit accumulation previously observed in PAH. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 700 | 1 | a Rådegran, Göranu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-lungsjukdom - information, stöd och bemötande,Forskargrupper vid Lunds universitet,Lund Hemodynamic Lab,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Cardiopulmonary disease - information, support and reception,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-grd |
| 710 | 2 | a Kardiologib Sektion II4 org |
| 773 | 0 | t ERJ Open Researchd : European Respiratory Society (ERS)g 4:4q 4:4x 2312-0541 |
| 856 | 4 | u http://dx.doi.org/10.1183/23120541.00035-2018x freey FULLTEXT |
| 856 | 4 | u https://openres.ersjournals.com/content/erjor/4/4/00035-2018.full.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/850a9d98-57af-4b2c-a472-c9151a6f249a |
| 856 | 4 8 | u https://doi.org/10.1183/23120541.00035-2018 |
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