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Magnetically-assist...
Magnetically-assisted viral transduction (magnetofection) medical applications : An update
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- Azadpour, Behnam (författare)
- Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
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- Aharipour, Nazli (författare)
- Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
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- Paryab, Amirhosein (författare)
- Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
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- Omid, Hamed (författare)
- Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
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- Abdollahi, Sorosh (författare)
- Department of Biomedical Engineering, University of Calgary, Alberta, Canada
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- Madaah Hosseini, Hamidreza (författare)
- Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
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- Malek Khachatourian, Adrine (författare)
- Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
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- Toprak, Muhammet, 1973- (författare)
- KTH,Biomedicinsk fysik och röntgenfysik
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- Seifalian, Alexander M. (författare)
- Nanotechnology & Regenerative Medicine Commercialisation Centre (NanoRegMed Ltd, Nanoloom Ltd, & Liberum Health Ltd), London BioScience Innovation Centre, London, UK
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: Biomaterials Advances. - : Elsevier BV. - 2772-9516 .- 2772-9508. ; 154
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Gene therapy involves replacing a faulty gene or adding a new gene inside the body's cells to cure disease or improve the body's ability to fight disease. Its popularity is evident from emerging concepts such as CRISPR-based genome editing and epigenetic studies and has been moved to a clinical setting. The strategy for therapeutic gene design includes; suppressing the expression of pathogenic genes, enhancing necessary protein production, and stimulating the immune system, which can be incorporated into both viral and non-viral gene vectors. Although non-viral gene delivery provides a safer platform, it suffers from an inefficient rate of gene transfection, which means a few genes could be successfully transfected and expressed within the cells. Incorporating nucleic acids into the viruses and using these viral vectors to infect cells increases gene transfection efficiency. Consequently, more cells will respond, more genes will be expressed, and sustained and successful gene therapy can be achieved. Combining nanoparticles (NPs) and nucleic acids protects genetic materials from enzymatic degradation. Furthermore, the vectors can be transferred faster, facilitating cell attachment and cellular uptake. Magnetically assisted viral transduction (magnetofection) enhances gene therapy efficiency by mixing magnetic nanoparticles (MNPs) with gene vectors and exerting a magnetic field to guide a significant number of vectors directly onto the cells. This research critically reviews the MNPs and the physiochemical properties needed to assemble an appropriate magnetic viral vector, discussing cellular hurdles and attitudes toward overcoming these barriers to reach clinical gene therapy perspectives. We focus on the studies conducted on the various applications of magnetic viral vectors in cancer therapies, regenerative medicine, tissue engineering, cell sorting, and virus isolation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Cancer gene therapy
- Magnetic nanoparticles
- Magnetically-assisted viral gene delivery
- Magnetofection
- Transfection
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