SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:2772 9508
 

Sökning: L773:2772 9508 > Magnetically-assist...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004773naa a2200445 4500
001oai:DiVA.org:kth-339001
003SwePub
008231101s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3390012 URI
0247 a https://doi.org/10.1016/j.bioadv.2023.2136572 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Azadpour, Behnamu Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran4 aut
2451 0a Magnetically-assisted viral transduction (magnetofection) medical applications :b An update
264 1b Elsevier BV,c 2023
338 a print2 rdacarrier
500 a QC 20231101
520 a Gene therapy involves replacing a faulty gene or adding a new gene inside the body's cells to cure disease or improve the body's ability to fight disease. Its popularity is evident from emerging concepts such as CRISPR-based genome editing and epigenetic studies and has been moved to a clinical setting. The strategy for therapeutic gene design includes; suppressing the expression of pathogenic genes, enhancing necessary protein production, and stimulating the immune system, which can be incorporated into both viral and non-viral gene vectors. Although non-viral gene delivery provides a safer platform, it suffers from an inefficient rate of gene transfection, which means a few genes could be successfully transfected and expressed within the cells. Incorporating nucleic acids into the viruses and using these viral vectors to infect cells increases gene transfection efficiency. Consequently, more cells will respond, more genes will be expressed, and sustained and successful gene therapy can be achieved. Combining nanoparticles (NPs) and nucleic acids protects genetic materials from enzymatic degradation. Furthermore, the vectors can be transferred faster, facilitating cell attachment and cellular uptake. Magnetically assisted viral transduction (magnetofection) enhances gene therapy efficiency by mixing magnetic nanoparticles (MNPs) with gene vectors and exerting a magnetic field to guide a significant number of vectors directly onto the cells. This research critically reviews the MNPs and the physiochemical properties needed to assemble an appropriate magnetic viral vector, discussing cellular hurdles and attitudes toward overcoming these barriers to reach clinical gene therapy perspectives. We focus on the studies conducted on the various applications of magnetic viral vectors in cancer therapies, regenerative medicine, tissue engineering, cell sorting, and virus isolation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653 a Cancer gene therapy
653 a Magnetic nanoparticles
653 a Magnetically-assisted viral gene delivery
653 a Magnetofection
653 a Transfection
7001 a Aharipour, Nazliu Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran4 aut
7001 a Paryab, Amirhoseinu Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran4 aut
7001 a Omid, Hamedu Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran4 aut
7001 a Abdollahi, Soroshu Department of Biomedical Engineering, University of Calgary, Alberta, Canada4 aut
7001 a Madaah Hosseini, Hamidrezau Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran4 aut
7001 a Malek Khachatourian, Adrineu Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran4 aut
7001 a Toprak, Muhammet,d 1973-u KTH,Biomedicinsk fysik och röntgenfysik4 aut0 (Swepub:kth)u1u3m5a2
7001 a Seifalian, Alexander M.u Nanotechnology & Regenerative Medicine Commercialisation Centre (NanoRegMed Ltd, Nanoloom Ltd, & Liberum Health Ltd), London BioScience Innovation Centre, London, UK4 aut
7102 a Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iranb Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran4 org
7730 t Biomaterials Advancesd : Elsevier BVg 154q 154x 2772-9516x 2772-9508
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-339001
8564 8u https://doi.org/10.1016/j.bioadv.2023.213657

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy