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First-line treatmen...
First-line treatment of advanced ovarian cancer with paclitaxel/carboplatin with or without epirubicin (TEC versus TC)-a gynecologic cancer intergroup study of the NSGO, EORTC GCG and NCIC CTG
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- Lindemann, K. (author)
- Department of Gynecological Cancer, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
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- Christensen, R. D. (author)
- Department of Medical Statistics, University of Southern Denmark, Odense, Denmark
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- Vergote, I. (author)
- Department of Obstetrics and Gynecology, University Hospital Leuven, Leuven, Belgium
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- Stuart, G. (author)
- Department of Gynecologic Oncology, University of British Columbia, Vancouver, Canada
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- Izquierdo, M. A. (author)
- Institute of Oncology, Catalán Hospital, Catalania, Spain
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Kaem, J. (author)
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- Havsteen, H. (author)
- Department of Oncology, Herlev University Hospital, Herlev, Denmark,Department of Oncology, Division of Medical Oncology, Juravinski Cancer Centre, Hamilton, Ontario, Canada
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- Eisenhauer, E. (author)
- Karolinska Institutet
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- Ridderheim, Mona (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Gynecologic Oncology, Lund University Hospital, Lund, Sweden
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- Lopez, A. B. (author)
- Department of Gynecologic Oncology, Queen Elizabeth Hospital, Gateshead, UK
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Hirte, H. (author)
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- Åvall-Lundquvist, Elisabeth (author)
- Department of Oncology, Karolinska University Hospital, Stockholm, Sweden
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Vrdoljak, E. (author)
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- Green, J. (author)
- Department of Oncology, Clatterbridge Hospital, Wirral, UK
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- Kristensen, G. B. (author)
- Department of Gynecological Cancer, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway / Department of Gynecological Cancer, Institute for Medical Informatics, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
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- Kærn, J (author)
- Department of Gynecological Cancer, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 23:10, s. 31-2613
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Abstract
Subject headings
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- Background: The addition of anthracyclines to platinum-based chemotherapy may provide benefit in survival in ovarian cancer patients. We evaluated the effect on survival of adding epirubicin to standard carboplatin and paclitaxel. Patients and methods: We carried out a prospectively randomized phase III study comparing carboplatin plus paclitaxel (TC; area under the curve 5 and 175 mg/m(2)) with the same combination and epirubicin (TEC; 75 mg/m(2) i.v.). Between March 1999 and August 2001, 887 patients with epithelial ovarian, tubal or peritoneal cancer International Federation of Gynecology and Obstetrics stages IIB-IV were randomized to receive either TC (442 patients) or TEC (445 patients). Results: Median time to progression was 16.4 months in the TEC arm and 16.0 months in the TC arm (hazard ratio 0.99; 95% confidence interval [CI]: 0.9-1.2). Median overall survival time was 42.4 months for the TEC arm and 40.2 for the TC arm (hazard ratio 0.96; 95% CI: 0.8-1.1). Grade 3/4 hematologic toxic effects and most grade 3/4 non-hematologic toxic effects were more frequent in the TEC arm. Accordingly, a quality-of-life analysis showed inferiority of TEC versus TC. Conclusion: The addition of epirubicin to standard carboplatin and paclitaxel treatment did not improve survival in patients with advanced ovarian, tubal or peritoneal cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- epirubicin
- phase III study
- platinum-based chemotherapy
- ovarian
- cancer
- survival
- toxicity
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lindemann, K.
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Christensen, R. ...
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Vergote, I.
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Stuart, G.
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Izquierdo, M. A.
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Kaem, J.
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show more...
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Havsteen, H.
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Eisenhauer, E.
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Ridderheim, Mona
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Lopez, A. B.
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Hirte, H.
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Åvall-Lundquvist ...
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Vrdoljak, E.
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Green, J.
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Kristensen, G. B ...
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Kærn, J
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Annals of Oncolo ...
- By the university
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Lund University
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Linköping University
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Karolinska Institutet