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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005511naa a2200445 4500
001oai:DiVA.org:oru-65200
003SwePub
008180223s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-652002 URI
0247 a https://doi.org/10.1186/s12905-018-0531-22 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hadgu, Endaleu Department of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut
2451 0a Breast cancer in Ethiopia :b evidence for geographic difference in the distribution of molecular subtypes in Africa
264 c 2018-02-14
264 1b BioMed Central,c 2018
338 a print2 rdacarrier
500 a Funding Agencies:Addis Ababa University, School of Graduate Studies  Addis Ababa University, thematic research group "clinico-epidemiological characterization of breast cancer in Ethiopia"  Armauer Hansen Research Institute (AHRI)  Swedish International Developmental Agency (SIDA) 
520 a BACKGROUND: Breast cancer is a heterogeneous disease with several morphological and molecular subtypes. Widely accepted molecular classification system uses assessment of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and proliferation marker Ki67. Few studies have been conducted on the incidence and molecular types of breast cancer in Sub-Saharan Africa. Previous studies mainly from Western and Central Africa, showed breast cancer to occur at younger ages and to present with aggressive features, such as high-grade, advanced stage and triple-negative phenotype (negative for ER, PR and HER2). Limited data from East Africa including Ethiopia however shows hormone receptor negative tumors to account for a lower proportion of all breast cancers than has been reported from elsewhere in Africa.METHODS: In this study from Tikur Anbessa Specialized Hospital, 114 breast cancer patients diagnosed between 2012 and 2015 were enrolled. ER, PR, Ki67 and HER2 receptor status were assessed using immunohistochemistry from tissue microarrays. FISH was used for assessment of gene amplification in all equivocal tumor samples and for confirmation in HER2-enriched cases.RESULTS: The distribution of molecular subtypes was: Luminal A: 40%; Luminal B: 26%; HER2-enriched: 10%; TNBC: 23%. ER were positive in 65% of all tumors and 43% the cases were positive for PR. There was statistically significant difference in median age at diagnosis between the molecular subtypes (P < 0.05). There was a bimodal distribution of molecular subtypes in different age ranges with Luminal B subtype being more common at younger ages (median = 36) and Luminal A subtype more prevalent at older ages (median = 42). There were no statistically significant differences in tumor grade, histology, and stage between the molecular subtypes of breast cancer.CONCLUSION: The present study detected Luminal A breast cancer to be the most common subtype and reveals a relatively low rate of hormone receptor negative and TNBC. Our findings and results from other East African studies suggest geographic variability in the distribution of the molecular subtypes of breast cancer in Africa and hence have important clinical and policy implications for breast cancer control and treatment in Ethiopia.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Breast cancer; Molecular subtypes; Ethiopia; Africa
7001 a Seifu, Danielu Department of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut
7001 a Tigneh, Wondemagegnhuu Department of Oncology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut
7001 a Bokretsion, Yonasu Department of Pathology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut
7001 a Bekele, Abebeu Department of Surgery, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut
7001 a Abebe, Markosu Armauer Hansen research Institute (AHRI), Addis Ababa, Ethiopia4 aut
7001 a Sollie, Thomasu Dept of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden4 aut
7001 a Merajver, Sofia D.u University of Michigan Comprehensive Cancer Center, Ann Arbor MI, USA4 aut
7001 a Karlsson, Christina,d 1968-u Örebro universitet,Institutionen för hälsovetenskaper4 aut0 (Swepub:oru)ckn
7001 a Karlsson, Mats,d 1960-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)mskn
7102 a Department of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopiab Department of Oncology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 org
7730 t BMC Women's Healthd : BioMed Centralg 18:1q 18:1x 1472-6874
8564 u https://doi.org/10.1186/s12905-018-0531-2y Fulltext
8564 u https://bmcwomenshealth.biomedcentral.com/track/pdf/10.1186/s12905-018-0531-2
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-65200
8564 8u https://doi.org/10.1186/s12905-018-0531-2

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