Search: WFRF:(Al Khalili Szigyarto Cristina)
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Large-scale proteom...
Large-scale proteomics analysis of human ovarian cancer for biomarkers
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Bengtsson, Sofia (author)
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- Krogh, Morten (author)
- Lund University,Lunds universitet,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science
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- Al-Khalili Szigyarto, Cristina (author)
- KTH,Proteomik
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- Uhlén, Mathias (author)
- KTH,Proteomik
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Schedvins, Kjell (author)
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Silfversward, Claes (author)
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- Linder, Stig (author)
- Karolinska Institutet
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- Auer, Gert (author)
- Karolinska Institutet
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Alaiya, Ayodele (author)
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- James, Peter (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH
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(creator_code:org_t)
- 2007-02-22
- 2007
- English.
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In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 6:4, s. 1440-1450
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Ovarian cancer is usually found at a late stage when the prognosis is often bad. Relative survival rates decrease with tumor stage or grade, and the 5-year survival rate for women with carcinoma is only 38%. Thus, there is a great need to find biomarkers that can be used to carry out routine screening, especially in high-risk patient groups. Here, we present a large-scale study of 64 tissue samples taken from patients at all stages and show that we can identify statistically valid markers using nonsupervised methods that distinguish between normal, benign, borderline, and malignant tissue. We have identified 217 of the significantly changing protein spots. We are expressing and raising antibodies to 35 of these. Currently, we have validated 5 of these antibodies for use in immunohistochemical analysis using tissue microarrays of healthy and diseased ovarian, as well as other, human tissues.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Keyword
- biomarkers
- ovarian cancer
- DIGE
- proteomics
- statistical analysis
- lung-cancer
- cathepsin-b
- 2-dimensional electrophoresis
- gel-electrophoresis
- protein expression
- colon-cancer
- cell-lines
- breast
- carcinoma
- overexpression
Publication and Content Type
- ref (subject category)
- art (subject category)
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