In vitro and in vivo degradation profile of aliphatic polyesters subjected to electron beam sterilization

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Fältnamn	Indikatorer	Metadata
000		04305naa a2200517 4500
001		oai:DiVA.org:kth-34405
003		SwePub
008		110607s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-344052 URI
024	7	a https://doi.org/10.1016/j.actbio.2011.02.0112 DOI
040		a (SwePub)kth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Dånmark, Staffanu KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u1rvvxzs
245	1 0	a In vitro and in vivo degradation profile of aliphatic polyesters subjected to electron beam sterilization
264	1	b Elsevier BV,c 2011
338		a print2 rdacarrier
500		a QC 20150727
520		a Degradation characteristics in response to electron beam sterilization of designed and biodegradable aliphatic polyester scaffolds are relevant for clinically successful synthetic graft tissue regeneration Scaffold degradation in vitro and in vivo were documented and correlated to the macroscopic structure and chemical design of the original polymer The materials tested were of inherently diverse hydrophobicity and crystallinity poly(L-lactide) (poly(LLA)) and random copolymers from L-lactide and epsilon-caprolactone or 1.5-dioxepan-2-one, fabricated into porous and non-porous scaffolds After sterilization, the samples underwent hydrolysis in vitro for up to a year In vivo, scaffolds were surgically implanted into rat calvarial defects and retrieved for analysis after 28 and 91 days In vitro, poly(L-lactide-co-1, 5-dioxepan-2-one) (poly(LLA-co-DXO)) samples degraded most rapidly during hydrolysis, due to the pronounced chain-shortening reaction caused by the sterilization. This was indicated by the rapid decrease in both mass and molecular weight of poly(LLA-co-DXO). Poly(L-lactide-co-epsilon-caprolactone) (poly(LLA-co-CL)) samples were also strongly affected by sterilization, but mass loss was more gradual; molecular weight decreased rapidly during hydrolysis Least affected by sterilization were the poly(LLA) samples, which subsequently showed low mass loss rate and molecular weight decrease during hydrolysis. Mechanical stability varied greatly. poly(LLA-co-CL) withstood mechanical testing for up to 182 days, while poly(LLA) and poly(LLA-co-DXO) samples quickly became too brittle Poly(LLA-co-DXO) samples unexpectedly degraded more rapidly in vitro than in vivo. After sterilization by electron beam irradiation, the three biodegradable polymers present widely diverse degradation profiles, both in vitro and in vivo. Each exhibits the potential to be tailored to meet diverse clinical tissue engineering requirements
650	7	a TEKNIK OCH TEKNOLOGIERx Industriell bioteknikx Annan industriell bioteknik0 (SwePub)209992 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Industrial Biotechnologyx Other Industrial Biotechnology0 (SwePub)209992 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Materialteknik0 (SwePub)2052 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Materials Engineering0 (SwePub)2052 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Kemiteknikx Polymerteknologi0 (SwePub)204032 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Chemical Engineeringx Polymer Technologies0 (SwePub)204032 hsv//eng
653		a Aliphatic polyesters
653		a Electron beam sterilization
653		a Degradation
653		a Tissue engineering
653		a Scaffolds
653		a Other bioengineering
653		a
653		a Materials science
653		a Teknisk materialvetenskap
700	1	a Finne-Wistrand, Annau KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u17gwfv7
700	1	a Schander, K.4 aut
700	1	a Hakkarainen, Minnau KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u14e229n
700	1	a Arvidson, K.4 aut
700	1	a Mustafa, K.4 aut
700	1	a Albertsson, Ann-Christineu KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u1mpsp3u
710	2	a KTHb Fiber- och polymerteknologi4 org
773	0	t ACTA BIOMATERIALIAd : Elsevier BVg 7:5, s. 2035-2046q 7:5<2035-2046x 1742-7061
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-34405
856	4 8	u https://doi.org/10.1016/j.actbio.2011.02.011

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