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  • Rizzo, Roberta (author)

Allergic women have reduced sHLA-G plasma levels at delivery.

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-04-01
  • Wiley,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-32994
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-32994URI
  • https://doi.org/10.1111/j.1600-0897.2009.00703.xDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118566431URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • PROBLEM: HLA-G antigen maintains a tolerogenic condition at the foeto-maternal interface, counteracts inflammation in autoimmune diseases and soluble HLA-G (sHLA-G) levels decrease in allergic-asthmatics. Taking into consideration these findings, we analyzed if sHLA-G and interleukin-10 (IL-10) could be influenced by pregnancy and labour in allergic and non-allergic women. METHOD OF STUDY: sHLA-G isoforms and IL-10 levels were determined in the plasma samples of 43 women (15 non-allergic, 28 allergic) during third trimester, at delivery and 2 years after pregnancy by immunoenzymatic assays. RESULTS: A significant increase in sHLA-G and IL-10 levels was documented at delivery in both allergic and non-allergic women. Allergic women showed lower sHLA-G concentrations. sHLA-G1 was evidenced as the predominant plasma isoform. CONCLUSION: The data showed increased sHLA-G and IL-10 concentrations at delivery, regardless of the allergic status. The sHLA-G1 isoform is mainly responsible for the increased sHLA-G levels at delivery.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Stignani, Marina (author)
  • Amoudruz, PetraStockholms universitet,Avdelningen för immunologi (author)
  • Nilsson, CarolineKarolinska Institutet (author)
  • Melchiorri, Loredana (author)
  • Baricordi, Olavio (author)
  • Sverremark-Ekström, EvaStockholms universitet,Avdelningen för immunologi(Swepub:su)esver (author)
  • Stockholms universitetAvdelningen för immunologi (creator_code:org_t)

Related titles

  • In:American Journal of Reproductive Immunology and Microbiology: Wiley61:5, s. 368-768755-89201046-74081600-0897

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