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Sökning: WFRF:(Andreasen Niels) > (2020-2023) > Thrombocytopenia an...

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FältnamnIndikatorerMetadata
00005471naa a2200661 4500
001oai:lup.lub.lu.se:5ad84c4d-9a8b-4be8-bf10-bdabcc91a10a
003SwePub
008231015s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/5ad84c4d-9a8b-4be8-bf10-bdabcc91a10a2 URI
0247 a https://doi.org/10.1007/s00134-023-07225-22 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Anthon, Carl Thomasu Copenhagen University Hospital4 aut
2451 0a Thrombocytopenia and platelet transfusions in ICU patients : an international inception cohort study (PLOT-ICU)
264 1c 2023
520 a PURPOSE: Thrombocytopenia (platelet count < 150 × 10 9/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. METHODS: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.RESULTS: We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission, and 19.8% (17.6-22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19-2.42).CONCLUSION: Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
7001 a Pène, Frédéric4 aut
7001 a Perner, Anders4 aut
7001 a Barratt-Due, Andreasu Oslo university hospital4 aut
7001 a Chawla, Sanjayu Memorial Sloan-Kettering Cancer Center4 aut
7001 a Kander, Thomasu Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-tkn
7001 a Hästbacka, Johanna4 aut
7001 a Andreasen, Jo Bøndingu Aalborg University Hospital4 aut
7001 a Péju, Edwige4 aut
7001 a Nielsen, Lene Bjerregaardu Odense University Hospital4 aut
7001 a Hvas, Christine Lodbergu Aarhus University Hospital4 aut
7001 a Dufranc, Etienne4 aut
7001 a Canet, Emmanuel4 aut
7001 a Lundqvist, Linda4 aut
7001 a Wright, Christopher John4 aut
7001 a Voiriot, Guillaumeu Assistance Publique des Hôpitaux de Paris4 aut
7001 a Clausen, Niels Erikstrupu Bispebjerg Hospital4 aut
7001 a Lorentzen, Kristian4 aut
7001 a Kvåle, Reidaru Haukeland University Hospital4 aut
7001 a Hildebrandt, Thomas4 aut
7001 a Holten, Aleksander Ryghu Oslo university hospital4 aut
7001 a Strand, Kristianu Stavanger University Hospital4 aut
7001 a Tzalavras, Asteriosu University Hospital Essen4 aut
7001 a Bestle, Morten Heiberg4 aut
7001 a Klepstad, Pål4 aut
7001 a Fernandez, Sarau University of Barcelona4 aut
7001 a Vimpere, Damien4 aut
7001 a Paulino, Carolinau NOVA University Lisbon4 aut
7001 a Costa, Carolina4 aut
7001 a Bådstøløkken, Per Martin4 aut
7001 a Miranda, Teresau Centro Hospitalar de Lisboa Ocidental (CHLO)4 aut
7001 a Russell, Leneu Copenhagen University Hospital4 aut
7102 a Copenhagen University Hospitalb Oslo university hospital4 org
7102 a PLOT-ICU Investigators and the Nine-I Study Group
7730 t Intensive Care Medicineg 49:11, s. 1327-1338q 49:11<1327-1338x 0342-4642
8564 u http://dx.doi.org/10.1007/s00134-023-07225-2x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/5ad84c4d-9a8b-4be8-bf10-bdabcc91a10a
8564 8u https://doi.org/10.1007/s00134-023-07225-2

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