Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

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MARC

Gao, YXXuzhou Medical University (author)

Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Article/chapterEnglish2020

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2020-07-22
Springer Science and Business Media LLC,2020

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:144324988
http://kipublications.ki.se/Default.aspx?queryparsed=id:144324988URI
https://doi.org/10.1038/s41598-020-68848-9DOI
https://lup.lub.lu.se/record/292de28e-8974-48d7-a4f1-6e3913ecad00URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93–1.31, p = 0.274) in the European population and 0.75 (95% CI 0.53–1.07, p = 0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population.

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LANDQVIST WALDÖ, MARIALund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund(Swepub:lu)med-mlv (author)
Yu, XH (author)
Zhao, HS (author)
Zeng, PXuzhou Medical University (author)
Ferrari, R (author)
Hernandez, DG (author)
Nails, MA (author)
Rohrers, JD (author)
Ramasamys, A (author)
Kwok, JBJ (author)
Dobson-Stone, C (author)
Brooks, WS (author)
Schofield, PR (author)
Halliday, GM (author)
Hodges, JR (author)
Piguet, O (author)
Bartley, L (author)
Thompson, E (author)
Haan, E (author)
Hernandez, I (author)
Ruiz, A (author)
Boada, M (author)
Borronils, B (author)
Padovani, A (author)
Cruchaga, C (author)
Cairns, NJ (author)
Benussi, L (author)
Binetti, G (author)
Ghidoni, R (author)
Forloni, G (author)
Albani, D (author)
Galimberti, D (author)
Fenoglio, C (author)
Serpente, M (author)
Scarpini, E (author)
Clarim, J (author)
Lie, A (author)
Blesa, R (author)
Waldo, ML (author)
Nilsson, KarinLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-kan (author)
Nilsson, ChristerLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)neur-cni (author)
Mackenzie, IRA (author)
Hsiung, GYR (author)
Mann, DMA (author)
Grafman, J (author)
Morris, CM (author)
Attems, J (author)
Griffiths, TD (author)
McKeith, IG (author)
Thomas, AJ (author)
Pietrini, P (author)
Huey, ED (author)
Wassermann, EM (author)
Baborie, A (author)
Jaros, E (author)
Tierney, MC (author)
Pastor, P (author)
Razquin, C (author)
Ortega-Cubero, S (author)
Alonso, E (author)
Perneczky, R (author)
Diehl-Schmid, J (author)
Alexopoulos, P (author)
Kurz, A (author)
Rainero, I (author)
Rubino, E (author)
Pinessi, L (author)
Rogaeva, E (author)
St George-Hyslop, P (author)
Rossi, G (author)
Tagliavini, F (author)
Giacconen, G (author)
Rowe, JB (author)
Schlachetzki, JCM (author)
Uphill, J (author)
Collinge, J (author)
Mead, S (author)
Danek, A (author)
Van Deerlin, VM (author)
Grossman, M (author)
Trojanowski, JQ (author)
van der Zee, J (author)
Cruts, M (author)
Van Broeckhoven, C (author)
Cappa, SF (author)
Leber, I (author)
Hannequin, D (author)
Golfier, V (author)
Vercelletto, M (author)
Brice, A (author)
Nacmias, B (author)
Sorbi, S (author)
Bagnoli, S (author)
Piaceri, I (author)
Nielsen, JE (author)
Hjermind, LE (author)
Riemenschneider, M (author)
Mayhaus, M (author)
Ibach, B (author)
Gasparoni, G (author)
Pichler, S (author)
Gu, W (author)
Rossor, MN (author)
Fox, NC (author)
Warren, JD (author)
Spillantini, MG (author)
Morris, HR (author)
Rizzu, P (author)
Heutink, P (author)
Snowden, JS (author)
Rollinson, S (author)
Richardson, A (author)
Gerhard, A (author)
Bruni, AC (author)
Maletta, R (author)
Frangipane, F (author)
Cupidi, C (author)
Bernardi, L (author)
Anfossi, M (author)
Gallo, M (author)
Conidi, ME (author)
Smirne, N (author)
Rademakers, R (author)
Baker, M (author)
Dickson, DW (author)
Graff-Radford, NR (author)
Petersen, RC (author)
Knopman, D (author)
Josephs, KA (author)
Boeve, BF (author)
Parisi, JE (author)
Seeley, WW (author)
Miller, BL (author)
Karydas, AM (author)
Rosen, H (author)
van Swieten, JC (author)
Dopper, EGP (author)
Seelaar, H (author)
Pijnenburg, YAL (author)
Scheltens, P (author)
Logroscino, G (author)
Capozzo, R (author)
Novelli, V (author)
Puca, AA (author)
Franceschi, M (author)
Postiglione, A (author)
Milan, G (author)
Sorrentino, P (author)
Kristiansen, M (author)
Huei-Hsin, G (author)
Graff, CC (author)
Pasquier, F (author)
Rollin, A (author)
Deramecourt, V (author)
Lebouvier, T (author)
Ferrucci, L (author)
Pickering-Brown, S (author)
Singleton, AB (author)
Hardy, J (author)
Momeni, P (author)
Xuzhou Medical UniversityKliniska Vetenskaper, Helsingborg (creator_code:org_t)

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In:Scientific reports: Springer Science and Business Media LLC10:1, s. 12184-2045-2322

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By the author/editor: Gao, YX; LANDQVIST WALDÖ, ...; Yu, XH; Zhao, HS; Zeng, P; Ferrari, R; show more...; Hernandez, DG; Nails, MA; Rohrers, JD; Ramasamys, A; Kwok, JBJ; Dobson-Stone, C; Brooks, WS; Schofield, PR; Halliday, GM; Hodges, JR; Piguet, O; Bartley, L; Thompson, E; Haan, E; Hernandez, I; Ruiz, A; Boada, M; Borronils, B; Padovani, A; Cruchaga, C; Cairns, NJ; Benussi, L; Binetti, G; Ghidoni, R; Forloni, G; Albani, D; Galimberti, D; Fenoglio, C; Serpente, M; Scarpini, E; Clarim, J; Lie, A; Blesa, R; Waldo, ML; Nilsson, Karin; Nilsson, Christe ...; Mackenzie, IRA; Hsiung, GYR; Mann, DMA; Grafman, J; Morris, CM; Attems, J; Griffiths, TD; McKeith, IG; Thomas, AJ; Pietrini, P; Huey, ED; Wassermann, EM; Baborie, A; Jaros, E; Tierney, MC; Pastor, P; Razquin, C; Ortega-Cubero, S; Alonso, E; Perneczky, R; Diehl-Schmid, J; Alexopoulos, P; Kurz, A; Rainero, I; Rubino, E; Pinessi, L; Rogaeva, E; St George-Hyslop ...; Rossi, G; Tagliavini, F; Giacconen, G; Rowe, JB; Schlachetzki, JC ...; Uphill, J; Collinge, J; Mead, S; Danek, A; Van Deerlin, VM; Grossman, M; Trojanowski, JQ; van der Zee, J; Cruts, M; Van Broeckhoven, ...; Cappa, SF; Leber, I; Hannequin, D; Golfier, V; Vercelletto, M; Brice, A; Nacmias, B; Sorbi, S; Bagnoli, S; Piaceri, I; Nielsen, JE; Hjermind, LE; Riemenschneider, ...; Mayhaus, M; Ibach, B; Gasparoni, G; Pichler, S; Gu, W; Rossor, MN; Fox, NC; Warren, JD; Spillantini, MG; Morris, HR; Rizzu, P; Heutink, P; Snowden, JS; Rollinson, S; Richardson, A; Gerhard, A; Bruni, AC; Maletta, R; Frangipane, F; Cupidi, C; Bernardi, L; Anfossi, M; Gallo, M; Conidi, ME; Smirne, N; Rademakers, R; Baker, M; Dickson, DW; Graff-Radford, N ...; Petersen, RC; Knopman, D; Josephs, KA; Boeve, BF; Parisi, JE; Seeley, WW; Miller, BL; Karydas, AM; Rosen, H; van Swieten, JC; Dopper, EGP; Seelaar, H; Pijnenburg, YAL; Scheltens, P; Logroscino, G; Capozzo, R; Novelli, V; Puca, AA; Franceschi, M; Postiglione, A; Milan, G; Sorrentino, P; Kristiansen, M; Huei-Hsin, G; Graff, CC; Pasquier, F; Rollin, A; Deramecourt, V; Lebouvier, T; Ferrucci, L; Pickering-Brown, ...; Singleton, AB; Hardy, J; Momeni, P; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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