SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Bass Gary Alan 1979 )
 

Sökning: WFRF:(Bass Gary Alan 1979 ) > Pharmacological dif...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005225naa a2200433 4500
001oai:DiVA.org:oru-98332
003SwePub
008220330s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:149172496
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-983322 URI
0247 a https://doi.org/10.1038/s41598-022-08736-62 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1491724962 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ekestubbe, Lovisau School of Medical Sciences, Örebro University, Örebro, Sweden4 aut
2451 0a Pharmacological differences between beta-blockers and postoperative mortality following colon cancer surgery
264 c 2022-03-28
264 1b Nature Publishing Group,c 2022
338 a print2 rdacarrier
500 a Funding agency:Örebro University
520 a β-blocker therapy has been positively associated with improved survival in patients undergoing oncologic colorectal resection. This study investigates if the type of β-blocker used affects 90-day postoperative mortality following colon cancer surgery. The study was designed as a nationwide retrospective cohort study including all adult (≥ 18 years old) patients with ongoing β-blocker therapy who underwent elective and emergency colon cancer surgery in Sweden between January 1, 2007 and December 31, 2017. Patients were divided into four cohorts: metoprolol, atenolol, bisoprolol, and other beta-blockers. The primary outcome of interest was 90-day postoperative mortality. A Poisson regression model with robust standard errors was used, while adjusting for all clinically relevant variables, to determine the association between different β-blockers and 90-day postoperative mortality. A total of 9254 patients were included in the study. There was no clinically significant difference in crude 90-day postoperative mortality rate [n (%)] when comparing the four beta-blocker cohorts metoprolol, atenolol, bisoprolol and other beta-blockers. [97 (1.8%) vs. 28 (2.0%) vs. 29 (1.7%) vs. 11 (1.2%), p = 0.670]. This remained unchanged when adjusting for relevant covariates in the Poisson regression model. Compared to metoprolol, there was no statistically significant decrease in the risk of 90-day postoperative mortality with atenolol [adj. IRR (95% CI): 1.45 (0.89-2.37), p = 0.132], bisoprolol [adj. IRR (95% CI): 1.45 (0.89-2.37), p = 0.132], or other beta-blockers [adj. IRR (95% CI): 0.92 (0.46-1.85), p = 0.825]. In patients undergoing colon cancer surgery, the risk of 90-day postoperative mortality does not differ between the investigated types of β-adrenergic blocking agents.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Bass, Gary Alan,d 1979-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)gbs
7001 a Forssten, Maximilian Peter,d 1996-u Örebro universitet,Institutionen för medicinska vetenskaper,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)mmfn
7001 a Sjölin, Gabriel,d 1979-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)glsn
7001 a Cao, Yang,c Associate Professor,d 1972-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)yco
7001 a Matthiessen, Peter,d 1957-u Örebro universitet,Institutionen för medicinska vetenskaper,Division of Colorectal Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)pemn
7001 a Ahl, Rebecka,d 1987-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Trauma and Emergency Surgery, Department of Surgery, Karolinska University Hospital, Stockholm, Sweden; Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)raal
7001 a Mohseni, Shahin,d 1978-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)snmi
7102 a School of Medical Sciences, Örebro University, Örebro, Swedenb Institutionen för medicinska vetenskaper4 org
7730 t Scientific Reportsd : Nature Publishing Groupg 12:1q 12:1x 2045-2322
8564 u https://doi.org/10.1038/s41598-022-08736-6y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98332
8564 8u https://doi.org/10.1038/s41598-022-08736-6
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:149172496

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy