WFRF:(Bauren G)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02424naa a2200325 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1955417 | |
| 003 | SwePub | |
| 008 | 240701s2002 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19554172 URI |
| 024 | 7 | a https://doi.org/10.1091/mbc.e02-03-01382 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bjork, P4 aut |
| 245 | 1 0 | a A novel conserved RNA-binding domain protein, RBD-1, is essential for ribosome biogenesis |
| 264 | 1 | b American Society for Cell Biology (ASCB),c 2002 |
| 520 | a Synthesis of the ribosomal subunits from pre-rRNA requires a large number of trans-acting proteins and small nucleolar ribonucleoprotein particles to execute base modifications, RNA cleavages, and structural rearrangements. We have characterized a novel protein, RNA-binding domain-1 (RBD-1), that is involved in ribosome biogenesis. This protein contains six consensus RNA-binding domains and is conserved as to sequence, domain organization, and cellular location from yeast to human. RBD-1 is essential in Caenorhabditis elegans. In the dipteran Chironomus tentans, RBD-1 (Ct-RBD-1) binds pre-rRNA in vitro and anti-Ct-RBD-1 antibodies repress pre-rRNA processing in vivo. Ct-RBD-1 is mainly located in the nucleolus in an RNA polymerase I transcription-dependent manner, but it is also present in discrete foci in the interchromatin and in the cytoplasm. In cytoplasmic extracts, 20–30% of Ct-RBD-1 is associated with ribosomes and, preferentially, with the 40S ribosomal subunit. Our data suggest that RBD-1 plays a role in structurally coordinating pre-rRNA during ribosome biogenesis and that this function is conserved in all eukaryotes. | |
| 700 | 1 | a Bauren, G4 aut |
| 700 | 1 | a Jin, SB4 aut |
| 700 | 1 | a Tong, YG4 aut |
| 700 | 1 | a Burglin, TRu Karolinska Institutet4 aut |
| 700 | 1 | a Hellman, U4 aut |
| 700 | 1 | a Wieslander, L4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Molecular biology of the celld : American Society for Cell Biology (ASCB)g 13:10, s. 3683-3695q 13:10<3683-3695x 1059-1524x 1939-4586 |
| 856 | 4 | u https://europepmc.org/articles/pmc129975?pdf=render |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1955417 |
| 856 | 4 8 | u https://doi.org/10.1091/mbc.e02-03-0138 |
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