Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

Aqueveque, Pedro (author)

Leonardo Cespedes, Carlos (author)

Becerra, Jose (author)

Davila, Marcelo (author)

Sterner, Olov (author): Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH

(creator_code:org_t)

2015-05-28
2015
English.
In: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences. - : Walter de Gruyter GmbH. - 0939-5075. ; 70:3-4, s. 97-102

Related links:: http://dx.doi.org/10...; show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Abstract Subject headings

Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.

By the author/editor: Aqueveque, Pedro; Leonardo Cespede ...; Becerra, Jose; Davila, Marcelo; Sterner, Olov

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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