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Defective oligodend...
Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.
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Fruttiger, M (författare)
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Karlsson, L (författare)
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Hall, A C (författare)
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Abramsson, A (författare)
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Calver, A R (författare)
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- Boström, Hans (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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Willetts, K (författare)
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Bertold, C H (författare)
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Heath, J K (författare)
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Betsholtz, C (författare)
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Richardson, W D (författare)
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(creator_code:org_t)
- 1999
- 1999
- Engelska.
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Ingår i: Development. - 0950-1991. ; 126:3, s. 457-67
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- There is a class of oligodendrocyte progenitors, called O-2A progenitors, that is characterized by expression of platelet-derived growth factor alpha-receptors (PDGFRalpha). It is not known whether all oligodendrocytes are derived from these PDGFRalpha-progenitors or whether a subset(s) of oligodendrocytes develops from a different, PDGFR alpha-negative lineage(s). We investigated the relationship between PDGF and oligodendrogenesis by examining mice that lack either PDGF-A or PDGF-B. PDGF-A null mice had many fewer PDGFR alpha-progenitors than either wild-type or PDGF-B null mice, demonstrating that proliferation of these cells relies heavily (though not exclusively) on PDGF-AA homodimers. PDGF-A-deficient mice also had reduced numbers of oligodendrocytes and a dysmyelinating phenotype (tremor). Not all parts of the central nervous system (CNS) were equally affected in the knockout. For example, there were profound reductions in the numbers of PDGFR alpha-progenitors and oligodendrocytes in the spinal cord and cerebellum, but less severe reductions of both cell types in the medulla. This correlation suggests a close link between PDGFRalpha-progenitors and oligodendrogenesis in most or all parts of the CNS. We also provide evidence that myelin proteolipid protein (PLP/DM-20)-positive cells in the late embryonic brainstem are non-dividing cells, presumably immature oligodendrocytes, and not proliferating precursors.
Nyckelord
- Animals
- Brain/embryology
- Cell Differentiation
- Cell Division
- Central Nervous System/*embryology
- Mice
- Mice; Knockout
- Myelin Proteolipid Protein/physiology
- Myelin Sheath/*physiology
- Oligodendroglia/*physiology
- Platelet-Derived Growth Factor/genetics/*physiology
- Proto-Oncogene Proteins/genetics/physiology
- Proto-Oncogene Proteins c-sis
- Receptor; Platelet-Derived Growth Factor alpha
- Receptors; Platelet-Derived Growth Factor/genetics/physiology
- Research Support; Non-U.S. Gov't
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Fruttiger, M
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Karlsson, L
-
Hall, A C
-
Abramsson, A
-
Calver, A R
-
Boström, Hans
-
visa fler...
-
Willetts, K
-
Bertold, C H
-
Heath, J K
-
Betsholtz, C
-
Richardson, W D
-
visa färre...
- Artiklar i publikationen
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Development
- Av lärosätet
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Uppsala universitet