Sökning: WFRF:(Betthauser T. J.) > (2022) > Crosswalk study on ...
Fältnamn | Indikatorer | Metadata |
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000 | 04429naa a2200613 4500 | |
001 | oai:gup.ub.gu.se/314097 | |
003 | SwePub | |
008 | 240528s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3140972 URI |
024 | 7 | a https://doi.org/10.1002/dad2.122662 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jonaitis, E. M.4 aut |
245 | 1 0 | a Crosswalk study on blood collection-tube types for Alzheimer's disease biomarkers |
264 | c 2022-02-09 | |
264 | 1 | b Wiley,c 2022 |
520 | a Introduction Blood-based Alzheimer's disease (AD) biomarkers show promise, but pre-analytical protocol differences may pose problems. We examined seven AD blood biomarkers (amyloid beta [A beta]42${\rm{A\beta }}]{_{42}}$, A beta 40${\rm{A}}{{{\beta}}_{40}}$, phosphorylatedtau[p-tau181${\rm{phosphorylated\;tau\;[p - ta}}{{\rm{u}}_{181}}$, total tau [t-tau], neurofilament light chain [NfL], A beta 4240,${\rm{A}}{{{\beta}}_{\frac{{42}}{{40}}}},$ and p-tau181A beta 42$\frac{{{\rm{p - ta}}{{\rm{u}}_{181}}}}{{{\rm{A}}{{{\beta}}_{42}}}}$) in three collection tube types (ethylenediaminetetraacetic acid [EDTA] plasma, heparin plasma, serum). Methods Plasma and serum were obtained from cerebrospinal fluid or amyloid positron emission tomography-positive and -negative participants (N = 38) in the Wisconsin Registry for Alzheimer's Prevention. We modeled AD biomarker values observed in EDTA plasma versus heparin plasma and serum, and assessed correspondence with brain amyloidosis. Results Results suggested bias due to tube type, but crosswalks are possible for some analytes, with excellent model fit for NfL (R2${{\rm{R}}<^>2}\;$= 0.94), adequate for amyloid (R2${{\rm{R}}<^>2}\;$= 0.40-0.69), and weaker for t-tau (R2${{\rm{R}}<^>2}\;$= 0.04-0.42) and p-tau181${\rm{p - ta}}{{\rm{u}}_{181}}$ ( R2${{\rm{R}}<^>2}\;$= 0.22-0.29). Brain amyloidosis differentiated several measures, especially EDTA plasma pTau181A beta 42$\frac{{{\rm{pTa}}{{\rm{u}}_{181}}}}{{{\rm{A}}{\beta _{42}}}}$ (d$d\;$= 1.29). Discussion AD biomarker concentrations vary by tube type. However, correlations for some biomarkers support harmonization across types, suggesting cautious optimism for use in banked blood. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Alzheimer's disease | |
653 | a amyloid beta | |
653 | a cognitively unimpaired | |
653 | a neurofilament | |
653 | a light | |
653 | a plasma | |
653 | a p-tau181 | |
653 | a t-tau | |
653 | a sas procedure | |
653 | a Neurosciences & Neurology | |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Koscik, R. L.4 aut |
700 | 1 | a Betthauser, T. J.4 aut |
700 | 1 | a Van Hulle, C. A.4 aut |
700 | 1 | a Hogan, K.4 aut |
700 | 1 | a Hegge, L.4 aut |
700 | 1 | a Kollmorgen, G.4 aut |
700 | 1 | a Suridjan, I.4 aut |
700 | 1 | a Gleason, C. E.4 aut |
700 | 1 | a Engelman, C. D.4 aut |
700 | 1 | a Okonkwo, O. C.4 aut |
700 | 1 | a Asthana, S.4 aut |
700 | 1 | a Bendlin, B. B.4 aut |
700 | 1 | a Carlsson, C. M.4 aut |
700 | 1 | a Johnson, S. C.4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alzheimer's & Dementiad : Wileyg 14:1q 14:1x 1552-5260x 1552-5279 |
773 | 0 | t Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoringd : Wileyg 14:1q 14:1x 2352-8729x 2352-8729 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12266 |
856 | 4 8 | u https://gup.ub.gu.se/publication/314097 |
856 | 4 8 | u https://doi.org/10.1002/dad2.12266 |
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