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WFRF:(Boggavarapu NR)
 

Sökning: WFRF:(Boggavarapu NR) > Compartmentalized g...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002201naa a2200337 4500
001oai:prod.swepub.kib.ki.se:134301555
003SwePub
008240701s2016 | |||||||||||000 ||eng|
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1343015552 URI
024a https://doi.org/10.1038/srep338112 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Boggavarapu, NRu Karolinska Institutet4 aut
2451 0a Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form
264 c 2016-09-26
264 1b Springer Science and Business Media LLC,c 2016
520 a The complexity of endometrial receptivity at the molecular level needs to be explored in detail to improve the management of infertility. Here, differential expression of transcriptomes in receptive endometrial glands and stroma revealed Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a progesterone regulated factor and confirmed by various methods, both at mRNA and protein level. The involvement of ENPP3 in embryo attachment was tested in an in vitro model for human embryo implantation. Interestingly, there was high expression of ENPP3 mRNA in stroma but not protein. Presence of N-glycosylated ENPP3 in receptive phase uterine fluid in women confirms its regulation by progesterone and makes it possible to use in a non-invasive test of endometrial receptivity.
700a Lalitkumar, S4 aut
700a Joshua, Vu Karolinska Institutet4 aut
700a Kasvandik, S4 aut
700a Salumets, A4 aut
700a Lalitkumar, PGu Karolinska Institutet4 aut
700a Gemzell-Danielsson, Ku Karolinska Institutet4 aut
710a Karolinska Institutet4 org
773t Scientific reportsd : Springer Science and Business Media LLCg 6, s. 33811-q 6<33811-x 2045-2322
856u https://doi.org/10.1038/srep33811
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:134301555
8564 8u https://doi.org/10.1038/srep33811

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