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LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04766naa a2200433 4500 | |
| 001 | oai:DiVA.org:liu-50387 | |
| 003 | SwePub | |
| 008 | 091011s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-503872 URI |
| 024 | 7 | a https://doi.org/10.1152/ajpheart.00284.20082 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Krishnamurthy, G.u Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States, Department of Mechanical Engineering, Stanford University, Stanford, CA, United States4 aut |
| 245 | 1 0 | a Material properties of the ovine mitral valve anterior leaflet in vivo from inverse finite element analysis |
| 264 | 1 | b American Physiological Society,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a We measured leaflet displacements and used inverse finite-element analysis to define, for the first time, the material properties of mitral valve (MV) leaflets in vivo. Sixteen miniature radiopaque markers were sewn to the MV annulus, 16 to the anterior MV leaflet, and 1 on each papillary muscle tip in 17 sheep. Four-dimensional coordinates were obtained from biplane videofluoroscopic marker images (60 frames/s) during three complete cardiac cycles. A finite-element model of the anterior MV leaflet was developed using marker coordinates at the end of isovolumic relaxation (IVR, when the pressure difference across the valve is ~0), as the minimum stress reference state. Leaflet displacements were simulated during IVR using measured left ventricular and atrial pressures. The leaflet shear modulus (Gcirc-rad) and elastic moduli in both the commisure-commisure (Ecirc) and radial (Erad) directions were obtained using the method of feasible directions to minimize the difference between simulated and measured displacements. Group mean (±SD) values (17 animals, 3 heartbeats each, i.e., 51 cardiac cycles) were as follows: Gcirc-rad = 121 ± 22 N/mm2, Ecirc = 43 ± 18 N/mm2, and Erad = 11 ± 3 N/mm2 (Ecirc > E rad, P < 0.01). These values, much greater than those previously reported from in vitro studies, may result from activated neurally controlled contractile tissue within the leaflet that is inactive in excised tissues. This could have important implications, not only to our understanding of mitral valve physiology in the beating heart but for providing additional information to aid the development of more durable tissue-engineered bioprosthetic valves. Copyright © 2008 the American Physiological Society. | |
| 653 | a Inverse finite-element analysis | |
| 653 | a Mitral valve material properties | |
| 653 | a Ovine model | |
| 653 | a Radiopaque markers | |
| 653 | a TECHNOLOGY | |
| 653 | a TEKNIKVETENSKAP | |
| 700 | 1 | a Ennis, D.B.u Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States4 aut |
| 700 | 1 | a Itoh, A.u Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States4 aut |
| 700 | 1 | a Bothe, W.u Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States4 aut |
| 700 | 1 | a Swanson, J.C.u Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States4 aut |
| 700 | 1 | a Karlsson, Mattsu Linköpings universitet,Mekanisk värmeteori och strömningslära,Tekniska högskolan4 aut0 (Swepub:liu)matka16 |
| 700 | 1 | a Kuh, E.u Department of Mechanical Engineering, Stanford University, Stanford, CA, United States4 aut |
| 700 | 1 | a Miller, D.C.u Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States4 aut |
| 700 | 1 | a Ingels, Jr. N.B.u Ingels Jr., N.B., Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States, Laboratory of Cardiovascular Physiology and Biophysics, Research Institute, Palo Alto Medical Foundation, Palo Alto, CA, United States, Laboratory of Cardiovascular Physiology and Biophysics, Research Institute, Palo Alto Medical Foundation, 795 El Camino Real, Palo Alto, CA 94301-2302, United States4 aut |
| 710 | 2 | a Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States, Department of Mechanical Engineering, Stanford University, Stanford, CA, United Statesb Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States4 org |
| 773 | 0 | t American Journal of Physiology. Heart and Circulatory Physiologyd : American Physiological Societyg 295:3q 295:3x 0363-6135x 1522-1539 |
| 856 | 4 | u https://europepmc.org/articles/pmc2544494 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-50387 |
| 856 | 4 8 | u https://doi.org/10.1152/ajpheart.00284.2008 |
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