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Search: WFRF:(Brauer G) > (2005-2009) > Volume turnover kin...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003697naa a2200385 4500
001oai:DiVA.org:liu-100177
003SwePub
008131030s2005 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1958785
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1001772 URI
0247 a https://doi.org/10.1097/00000542-200505000-000182 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19587852 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Norberg, Åkeu Karolinska Institutet4 aut
2451 0a Volume turnover kinetics of fluid shifts after hemorrhage, fluid infusion, and the combination of hemorrhage and fluid infusion in sheep
264 1b Lippincott Williams & Wilkins,c 2005
338 a print2 rdacarrier
520 a BACKGROUND: Hemorrhage is commonly treated with intravenous infusion of crystalloids. However, the dynamics of fluid shifts between body fluid spaces are not completely known, causing contradictory recommendations regarding timing and volume of fluid infusions. The authors have developed a turnover model that characterizes these fluid shifts.METHODS: Conscious, chronically instrumented sheep (n = 12) were randomly assigned to three protocol groups: infusion of 25 ml/kg of 0.9% saline over 20 min (infusion only), hemorrhage of 300 ml (7.8 +/- 1.1 ml/kg) over 5 min (hemorrhage only), and hemorrhage of 300 ml over 5 min followed by infusion as noted above (hemorrhage plus infusion). A two-compartment volume turnover kinetic model containing seven model parameters was fitted to data obtained by repeated sampling of hemoglobin concentration and urinary excretion.RESULTS: The volume turnover model successfully predicted fluid shifts. Mean baseline volumes of the central and tissue compartments were 1799 +/- 1276 ml and 7653 +/- 5478 ml, respectively. Immediate fluid infusion failed to prevent hemorrhage-induced depression of cardiac output and diuresis. The model suggested that volume recruitment to the central compartment after hemorrhage was primarily achieved by mechanisms other than volume equilibration between the two model compartments.CONCLUSION: Volume turnover kinetics is a promising tool for explaining fluid shifts between body compartments after perturbations such as hemorrhage and intravenous fluid infusions. The pronounced inhibition of renal output after hemorrhage prevailed regardless of fluid infusion and caused fluid retention, which expanded the tissue compartment.
7001 a Brauer, Kirk Iu University of Texas Medical Branch, USA4 aut
7001 a Prough, Donald Su University of Texas Medical Branch, USA4 aut
7001 a Gabrielsson, Johanu Karolinska University Hospital, Huddinge, Stockholm, Sweden4 aut
7001 a Hahn, Robert Gu Karolinska Institutet4 aut0 (Swepub:liu)robha40
7001 a Uchida, Tatsuou University of Texas Medical Branch, USA4 aut
7001 a Traber, Daniel Lu University of Texas Medical Branch, USA4 aut
7001 a Svensén, Christer Hu Karolinska Institutet4 aut
7102 a Karolinska Institutetb University of Texas Medical Branch, USA4 org
7730 t Anesthesiologyd : Lippincott Williams & Wilkinsg 102:5, s. 985-994q 102:5<985-994x 0003-3022x 1528-1175
8564 u https://pubs.asahq.org/anesthesiology/article-pdf/102/5/985/354174/0000542-200505000-00018.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-100177
8564 8u https://doi.org/10.1097/00000542-200505000-00018
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1958785

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