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Weight change in mi...
Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study
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Emaus, Marleen J. (author)
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van Gils, Carla H. (author)
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Bakker, Marije F. (author)
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Bisschop, Charlotte N. Steins (author)
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Monninkhof, Evelyn M. (author)
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Bueno-de-Mesquita, H. B(as) (author)
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Travier, Noemie (author)
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Berentzen, Tina Landsvig (author)
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Overvad, Kim (author)
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Tjonneland, Anne (author)
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Romieu, Isabelle (author)
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Rinaldi, Sabina (author)
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Chajes, Veronique (author)
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Gunter, Marc J. (author)
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Clavel-Chapelon, Francoise (author)
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Fagherazzi, Guy (author)
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Mesrine, Sylvie (author)
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Chang-Claude, Jenny (author)
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Kaaks, Rudolf (author)
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Boeing, Heiner (author)
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Aleksandrova, Krasimira (author)
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Trichopoulou, Antonia (author)
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Naska, Androniki (author)
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Orfanos, Philippos (author)
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Palli, Domenico (author)
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Agnoli, Claudia (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Mattiello, Amalia (author)
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Braaten, Tonje (author)
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Borch, Kristin Benjaminsen (author)
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Lund, Eiliv (author)
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Menendez, Virginia (author)
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Sanchez, Maria-Jose (author)
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Navarro, Carmen (author)
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Barricarte, Aurelio (author)
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Amiano, Pilar (author)
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi
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- Andersson, Anne (author)
- Umeå universitet,Onkologi
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- Borgquist, Signe (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Olsson, Åsa (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Travis, Ruth C. (author)
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Riboli, Elio (author)
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Peeters, Petra H. M. (author)
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May, Anne M. (author)
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(creator_code:org_t)
- 2014-05-16
- 2014
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 135:12, s. 2887-2899
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- breast cancer
- adult weight gain
- menopausal status
- estrogen receptor
- progesterone receptor
- breast cancer
- adult weight gain
- menopausal status
- estrogen receptor
- progesterone receptor
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Emaus, Marleen J ...
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van Gils, Carla ...
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Bakker, Marije F ...
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Bisschop, Charlo ...
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Monninkhof, Evel ...
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Bueno-de-Mesquit ...
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show more...
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Travier, Noemie
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Berentzen, Tina ...
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Overvad, Kim
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Tjonneland, Anne
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Romieu, Isabelle
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Rinaldi, Sabina
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Chajes, Veroniqu ...
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Gunter, Marc J.
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Clavel-Chapelon, ...
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Fagherazzi, Guy
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Mesrine, Sylvie
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Chang-Claude, Je ...
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Kaaks, Rudolf
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Boeing, Heiner
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Aleksandrova, Kr ...
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Trichopoulou, An ...
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Naska, Androniki
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Orfanos, Philipp ...
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Palli, Domenico
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Agnoli, Claudia
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Tumino, Rosario
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Vineis, Paolo
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Mattiello, Amali ...
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Braaten, Tonje
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Borch, Kristin B ...
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Lund, Eiliv
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Menendez, Virgin ...
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Sanchez, Maria-J ...
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Navarro, Carmen
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Barricarte, Aure ...
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Amiano, Pilar
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Sund, Malin, 197 ...
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Andersson, Anne
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Borgquist, Signe
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Olsson, Åsa
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Khaw, Kay-Tee
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Wareham, Nick
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Travis, Ruth C.
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Riboli, Elio
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Peeters, Petra H ...
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May, Anne M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Lund University