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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04376naa a2200697 4500 | |
| 001 | oai:gup.ub.gu.se/206766 | |
| 003 | SwePub | |
| 008 | 240528s2014 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:129957308 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2067662 URI |
| 024 | 7 | a https://doi.org/10.1093/eurheartj/eht5322 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1299573082 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Akhmedov, A.4 aut |
| 245 | 1 0 | a Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo |
| 264 | c 2014-01-12 | |
| 264 | 1 | b Oxford University Press (OUP),c 2014 |
| 520 | a Aims Lectin-like oxLDL receptor-1 (LOX-1) mediates the uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells and macrophages. However, the different atherogenic potential of LOX-1-mediated endothelial and macrophage oxLDL uptake remains unclear. The present study was designed to investigate the in vivo role of endothelial LOX-1 in atherogenesis. Methods and results Endothelial-specific LOX-1 transgenic mice were generated using the Tie2 promoter (LOX-1TG). Oxidized low-density lipoprotein uptake was enhanced in cultured endothelial cells, but not in macrophages of LOX-1TG mice. Six-week-old male LOX-1TG and wild-type (WT) mice were fed a high-cholesterol diet (HCD) for 30 weeks. Increased reactive oxygen species production, impaired endothelial nitric oxide synthase activity and endothelial dysfunction were observed in LOX-1TG mice as compared with WT littermates. LOX-1 overexpression led to p38 phosphorylation, increased nuclear factor kappa B activity and subsequent up-regulation of vascular cell adhesion molecule-1, thereby favouring macrophage accumulation and aortic fatty streaks. Consistently, HCD-fed double-mutant LOX-1TG/ApoE(-/-) displayed oxidative stress and vascular inflammation with higher aortic plaques than ApoE(-/-) controls. Finally, bone marrow transplantation experiments showed that endothelial LOX-1 was sufficient for atherosclerosis development in vivo. Conclusions Endothelial-specific LOX-1 overexpression enhanced aortic oxLDL levels, thereby favouring endothelial dysfunction, vascular inflammation and plaque formation. Thus, LOX-1 may serve as a novel therapeutic target for atherosclerosis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a Endothelium | |
| 653 | a Vascular inflammation | |
| 653 | a Atherosclerosis | |
| 653 | a LOW-DENSITY-LIPOPROTEIN | |
| 653 | a ADHESION MOLECULE EXPRESSION | |
| 653 | a LECTIN-LIKE | |
| 653 | a OX-LDL | |
| 653 | a MONOCYTE ADHESION | |
| 653 | a KNOCKOUT MICE | |
| 653 | a CELLS | |
| 653 | a RECEPTOR-1 | |
| 653 | a ATHEROGENESIS | |
| 653 | a APOPTOSIS | |
| 700 | 1 | a Rozenberg, I.4 aut |
| 700 | 1 | a Paneni, F.u Karolinska Institutet4 aut |
| 700 | 1 | a Camici, G. G.4 aut |
| 700 | 1 | a Shi, Y.4 aut |
| 700 | 1 | a Doerries, C.4 aut |
| 700 | 1 | a Sledzinska, A.4 aut |
| 700 | 1 | a Mocharla, P.4 aut |
| 700 | 1 | a Breitenstein, A.4 aut |
| 700 | 1 | a Lohmann, C.4 aut |
| 700 | 1 | a Stein, S.4 aut |
| 700 | 1 | a von Lukowicz, T.4 aut |
| 700 | 1 | a Kurrer, M. O.4 aut |
| 700 | 1 | a Borén, Jan,d 1963u Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR)4 aut0 (Swepub:gu)xborej |
| 700 | 1 | a Becher, B.4 aut |
| 700 | 1 | a Tanner, F. C.4 aut |
| 700 | 1 | a Landmesser, U.4 aut |
| 700 | 1 | a Matter, C. M.4 aut |
| 700 | 1 | a Luscher, T. F.4 aut |
| 710 | 2 | a Karolinska Institutetb Center for Cardiovascular and Metabolic Research (CMR)4 org |
| 773 | 0 | t European Heart Journald : Oxford University Press (OUP)g 35:40, s. 2839-2848q 35:40<2839-2848x 0195-668Xx 1522-9645 |
| 856 | 4 | u https://academic.oup.com/eurheartj/article-pdf/35/40/2839/17354717/eht532.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/206766 |
| 856 | 4 8 | u https://doi.org/10.1093/eurheartj/eht532 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129957308 |
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- Akhmedov, A.
- Rozenberg, I.
- Paneni, F.
- Camici, G. G.
- Shi, Y.
- Doerries, C.
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- Sledzinska, A.
- Mocharla, P.
- Breitenstein, A.
- Lohmann, C.
- Stein, S.
- von Lukowicz, T.
- Kurrer, M. O.
- Borén, Jan, 1963
- Becher, B.
- Tanner, F. C.
- Landmesser, U.
- Matter, C. M.
- Luscher, T. F.
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