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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006562naa a2200661 4500
001oai:DiVA.org:uu-299719
003SwePub
008160726s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:133775050
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2997192 URI
0247 a https://doi.org/10.1182/blood-2015-12-6865502 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1337750502 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Georgiou, Konstantinosu Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.4 aut
2451 0a Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas
264 1b American Society of Hematology,c 2016
338 a print2 rdacarrier
520 a Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using whole-genome sequencing analysis, we have identified the PD-L1/PD-L2 locus as a recurrent translocation partner for IGH in DLBCL. PIM1 and TP63 were also identified as novel translocation partners for PD-L1/PD-L2. Fluorescence in situ hybridization was furthermore used to rapidly screen an expanded DLBCL cohort. Collectively, a subset of samples was found to be affected by gains (12%), amplifications (3%), and translocations (4%) of the PD-L1/PD-L2 locus. RNA sequencing data coupled with immunohistochemistry revealed that these cytogenetic alterations correlated with increased expression of PD-L1 but not of PD-L2. Moreover, cytogenetic alterations affecting the PD-L1/PD-L2 locus were more frequently observed in the non-germinal center B cell-like (non-GCB) subtype of DLBCL. These findings demonstrate the genetic basis of PD-L1 overexpression in DLBCL and suggest that treatments targeting the PD-1-PD-L1/PD-L2 axis might benefit DLBCL patients, especially those belonging to the more aggressive non-GCB subtype.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a Patologi
653 a Pathology
7001 a Chen, Longyunu Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China.4 aut
7001 a Berglund, Mattiasu Karolinska Institutet4 aut
7001 a Ren, Weichengu Karolinska Institutet4 aut
7001 a de Miranda, Noel F. C. C.u Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands.4 aut
7001 a Lisboa, Susanau Univ Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.4 aut
7001 a Fangazio, Marcou Columbia Univ, Inst Canc Genet, New York, NY USA.4 aut
7001 a Zhu, Shidau BGI Shenzhen, Shenzhen, Peoples R China.4 aut
7001 a Hou, Yongu BGI Shenzhen, Shenzhen, Peoples R China.4 aut
7001 a Wu, Kuiu BGI Shenzhen, Shenzhen, Peoples R China.4 aut
7001 a Fang, Wenfengu Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.4 aut
7001 a Wang, Xianhuou Tianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.4 aut
7001 a Meng, Binu Tianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.4 aut
7001 a Zhang, Liu Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.4 aut
7001 a Zeng, Yixinu Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.4 aut
7001 a Bhagat, Govindu Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA.4 aut
7001 a Nordenskjold, Magnusu Karolinska Institutet4 aut
7001 a Sundström, Christeru Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)chrisund
7001 a Enblad, Gunillau Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)gunienbl
7001 a Dalla-Favera, Riccardou Columbia Univ, Inst Canc Genet, New York, NY USA.4 aut
7001 a Zhang, Huilaiu Tianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.4 aut
7001 a Teixeira, Manuel R.u Univ Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.4 aut
7001 a Pasqualucci, Laurau Columbia Univ, Inst Canc Genet, New York, NY USA.4 aut
7001 a Peng, Roujunu Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.4 aut
7001 a Pan-Hammarstrom, Qiangu Karolinska Institutet4 aut
7102 a Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.b Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China.4 org
7730 t Bloodd : American Society of Hematologyg 127:24, s. 3026-3034q 127:24<3026-3034x 0006-4971x 1528-0020
8564 u https://ashpublications.org/blood/article-pdf/127/24/3026/1393975/3026.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299719
8564 8u https://doi.org/10.1182/blood-2015-12-686550
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:133775050

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