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Serum/plasma methyl...
Serum/plasma methylmercury determination by isotope dilution gas chromatography : inductively coupled plasma mass spectrometry
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Baxter, Douglas (author)
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- Faarinen, Mikko (author)
- ALS Scandinavia AB
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- Österlund, Helene (author)
- Luleå tekniska universitet,Geovetenskap och miljöteknik
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- Rodushkin, Ilya (author)
- Luleå tekniska universitet,Geovetenskap och miljöteknik
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- Christensen, Morten (author)
- ALS Scandinavia AB, Täby
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Analytica Chimica Acta. - : Elsevier BV. - 0003-2670 .- 1873-4324. ; 701:2, s. 134-138
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A method for the determination of methylmercury in plasma and serum samples was developed. The method uses isotope dilution with 198Hg-labelled methylmercury, extraction into dichloromethane, back-extraction into water, aqueous-phase ethylation, purge and trap collection, thermal desorption, separation by gas chromatography, and mercury isotope specific detection by inductively coupled plasma mass spectrometry. By spiking 2 mL sample with 1.2 ng tracer, measurements in a concentration interval of (0.007–2.9) μg L−1 could be performed with uncertainty amplification factors <2. A limit of quantification of 0.03 μg L−1 was estimated at 10 times the standard deviation of concentrations measured in preparation blanks. Within- and between-run relative standard deviations were <10% at added concentration levels of 0.14 μg L−1, 0.35 μg L−1 and 2.8 μg L−1, with recoveries in the range 82% to 110%. Application of the method to 50 plasma/serum samples yielded a median (mean; range) concentration of methylmercury of 0.081 (0.091; <0.03–0.19) μg L−1. This is the first time methylmercury has been directly measured in this kind of specimen, and is therefore the first estimate of a reference range.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Geokemi (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Geochemistry (hsv//eng)
Keyword
- Applied Geology
- Tillämpad geologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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