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Sökning: WFRF:(Comans Emile F I) > Toward Prediction o...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003468naa a2200409 4500
001oai:DiVA.org:uu-206563
003SwePub
008130902s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2065632 URI
0247 a https://doi.org/10.1158/1078-0432.CCR-12-37792 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a van der Veldt, Astrid A. M.4 aut
2451 0a Toward Prediction of Efficacy of Chemotherapy :b A Proof of Concept Study in Lung Cancer Patients Using [11C]docetaxel and Positron Emission Tomography
264 1c 2013
338 a print2 rdacarrier
520 a Purpose:Pharmacokinetics of docetaxel can be measured in vivo using positron emission tomography (PET) and a microdose of radiolabeled docetaxel ([11C]docetaxel). The objective of this study was to investigate whether a [11C]docetaxel PET microdosing study could predict tumor uptake of therapeutic doses of docetaxel.Experimental Design:Docetaxel-naïve lung cancer patients underwent 2 [11C]docetaxel PET scans; one after bolus injection of [11C]docetaxel and another during combined infusion of [11C]docetaxel and a therapeutic dose of docetaxel (75 mg·m−2). Compartmental and spectral analyses were used to quantify [11C]docetaxel tumor kinetics. [11C]docetaxel PET measurements were used to estimate the area under the curve (AUC) of docetaxel in tumors. Tumor response was evaluated using computed tomography scans.Results:Net rates of influx (Ki) of [11C]docetaxel in tumors were comparable during microdosing and therapeutic scans. [11C]docetaxel AUCTumor during the therapeutic scan could be predicted reliably using an impulse response function derived from the microdosing scan together with the plasma curve of [11C]docetaxel during the therapeutic scan. At 90 minutes, the accumulated amount of docetaxel in tumors was less than 1% of the total infused dose of docetaxel. [11C]docetaxel Ki derived from the microdosing scan correlated with AUCTumor of docetaxel (Spearman ρ = 0.715; P = 0.004) during the therapeutic scan and with tumor response to docetaxel therapy (Spearman ρ = −0.800; P = 0.010).Conclusions:Microdosing data of [11C]docetaxel PET can be used to predict tumor uptake of docetaxel during chemotherapy. The present study provides a framework for investigating the PET microdosing concept for radiolabeled anticancer drugs in patients.
7001 a Lubberink, Marku Uppsala universitet,Enheten för nuklearmedicin och PET4 aut0 (Swepub:uu)marklubb
7001 a Mathijssen, Ron H. J.4 aut
7001 a Loos, Walter J.4 aut
7001 a Herder, Gerarda J. M.4 aut
7001 a Greuter, Henri N.4 aut
7001 a Comans, Emile F. I.4 aut
7001 a Rutten, Hugo B.4 aut
7001 a Eriksson, Jonasu VU University Medical Center Amsterdam4 aut0 (Swepub:uu)joeri542
7001 a Windhorst, Albert D.4 aut
7001 a Hendrikse, N. Harry4 aut
7001 a Postmus, Pieter E.4 aut
7001 a Smit, Egbert F.4 aut
7001 a Lammertsma, Adriaan A.4 aut
7102 a Uppsala universitetb Enheten för nuklearmedicin och PET4 org
7730 t Clinical Cancer Researchg 19:15, s. 4163-4173q 19:15<4163-4173x 1078-0432x 1557-3265
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206563
8564 8u https://doi.org/10.1158/1078-0432.CCR-12-3779

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