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The landscape of vi...
The landscape of viral associations in human cancers
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- Zapatka, Marc (författare)
- German Cancer Research Centre
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- Borozan, Ivan (författare)
- Ontario Institute for Cancer Research
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- Brewer, Daniel S (författare)
- University of East Anglia
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- Iskar, Murat (författare)
- German Cancer Research Centre
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- Grundhoff, Adam (författare)
- Heinrich Pette Institut
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- Alawi, Malik (författare)
- Heinrich Pette Institut
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- Desai, Nikita (författare)
- University College London Hospital
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- Sültmann, Holger (författare)
- National Centre of Tumor Diseases,German Cancer Research Centre
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- Moch, Holger (författare)
- University Hospital of Zurich
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- Cooper, Colin S (författare)
- Earlham Institute
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- Eils, Roland (författare)
- German Cancer Research Centre
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- Ferretti, Vincent (författare)
- Ontario Institute for Cancer Research
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- Lichter, Peter (författare)
- German Cancer Research Centre
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- Borg, Åke (creator_code:cre_t)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Ringnér, Markus (creator_code:cre_t)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science
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- Staaf, Johan (creator_code:cre_t)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund
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- 2020-02-05
- 2020
- Engelska.
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 52:3, s. 320-330
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Abstract
Ämnesord
Stäng
- Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and-for a subset-whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein-Barr virus (EBV), hepatitis B virus (HBV) and human papilloma virus (HPV; for example, HPV16 or HPV18). The study revealed significant exclusivity of HPV and driver mutations in head-and-neck cancer and the association of HPV with APOBEC mutational signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladder and head-and-neck carcinoma. For HBV, HPV16, HPV18 and adeno-associated virus-2 (AAV2), viral integration was associated with local variations in genomic copy numbers. Integrations at the TERT promoter were associated with high telomerase expression evidently activating this tumor-driving process. High levels of endogenous retrovirus (ERV1) expression were linked to a worse survival outcome in patients with kidney cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- DNA Copy Number Variations
- DNA Tumor Viruses/genetics
- Genome, Human/genetics
- Hepatitis B virus/genetics
- Herpesvirus 4, Human/genetics
- Humans
- Mutation
- Neoplasms/genetics
- Papillomavirus Infections/genetics
- Promoter Regions, Genetic/genetics
- Telomerase/genetics
- Transcriptome
- Tumor Virus Infections/virology
- Virus Integration
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zapatka, Marc
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Borozan, Ivan
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Brewer, Daniel S
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Iskar, Murat
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Grundhoff, Adam
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Alawi, Malik
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visa fler...
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Desai, Nikita
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Sültmann, Holger
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Moch, Holger
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Cooper, Colin S
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Eils, Roland
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Ferretti, Vincen ...
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Lichter, Peter
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Borg, Åke
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Ringnér, Markus
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Staaf, Johan
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Nature Genetics
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