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FältnamnIndikatorerMetadata
00009529naa a2200697 4500
001oai:DiVA.org:oru-84063
003SwePub
008200630s2013 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-101453
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-840632 URI
0247 a https://doi.org/10.1097/MAO.0b013e318288646a2 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1014532 URI
040 a (SwePub)orud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hendrickx, Jan-Jaapu University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium; Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium4 aut
2451 0a Familial aggregation of pure tone hearing thresholds in an aging European population
264 1b Lippincott Williams & Wilkins,c 2013
338 a print2 rdacarrier
520 a OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated.STUDY DESIGN: Multicenter survey in 8 European centers.SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study.RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies.DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oto-rhino-laryngologi0 (SwePub)302182 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Otorhinolaryngology0 (SwePub)302182 hsv//eng
7001 a Huyghe, Jeroen R.u Department of Medical Genetics, University of Antwerp, Antwerp, Belgium4 aut
7001 a Topsakal, Vedatu University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium4 aut
7001 a Demeester, Kellyu University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium4 aut
7001 a Wienker, Thomas F.u Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany4 aut
7001 a Laer, Lut Vanu University of Antwerp, Belgium4 aut
7001 a Eyken, Els Vanu Department of Medical Genetics, University of Antwerp, Antwerp, Belgium4 aut
7001 a Fransen, Eriku Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium4 aut
7001 a Mäki-Torkko, Elina,d 1961-u Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu; and Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland4 aut0 (Swepub:liu)elima30
7001 a Hannula, Samuliu Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland,University of Oulu and Oulu University Hospital, Finland4 aut
7001 a Parving, Agneteu Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark4 aut
7001 a Jensen, Monau Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark4 aut
7001 a Tropitzsch, Ankeu Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark,University of Tuebingen, Germany4 aut
7001 a Bonaconsa, Amandau Department of Otorhinolaryngology, University of Tubingen, Tubingen, Germany,University Hospital Padova, Italy4 aut
7001 a Mazzoli, Manuelau Department of Otorhinolaryngology, University of Tubingen, Tubingen, Germany,University Hospital Padova, Italy4 aut
7001 a Espeso, Angelesu Department of Otosurgery, University Hospital Padova, Padova, Italy,University Hospital of Wales, Cardiff, UK4 aut
7001 a Verbruggen, Katjau Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium4 aut
7001 a Huyghe, Jokeu Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium4 aut
7001 a Huygen, Patrick L. M.u Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre and Donders Institute for Brain, Cognition and Behaviour, the Netherlands4 aut
7001 a Kremer, Hannieu Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands4 aut
7001 a Kunst, Sylvia J.u Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands4 aut
7001 a Diaz-Lacava, Amalia N.u Pharmacoepidemiology in Neurodegenerative Disorders, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany4 aut
7001 a Steffens, Michaelu Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany4 aut
7001 a Pyykkö, Ilmariu Department of Otorhinolaryngology, University of Tampere, Tampere, Finland4 aut
7001 a Dhooge, Ingeborgu Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium4 aut
7001 a Stephens, Dafyddu Department of Otosurgery, University Hospital Padova, Padova, Italy,University Hospital of Wales, Cardiff, UK4 aut
7001 a Orzan, Evau Audiology and Otolaryngology Unit, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy4 aut
7001 a Pfister, Markus H. F.u Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark,University of Tuebingen, Germany4 aut
7001 a Bille, Michaelu Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark4 aut
7001 a Sorri, Marttiu Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland,University of Oulu and Oulu University Hospital, Finland4 aut
7001 a Cremers, Cor W. R. J.u Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands4 aut
7001 a Camp, Guy Vanu Department of Medical Genetics, University of Antwerp, Antwerp, Belgium4 aut
7001 a de Heyning, Paul Vanu University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium4 aut
7102 a University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium; Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgiumb Department of Medical Genetics, University of Antwerp, Antwerp, Belgium4 org
7730 t Otology and Neurotologyd : Lippincott Williams & Wilkinsg 34:5, s. 838-844q 34:5<838-844x 1531-7129x 1537-4505
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84063
8564 8u https://doi.org/10.1097/MAO.0b013e318288646a
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101453

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