Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.

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Fältnamn	Indikatorer	Metadata
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001		oai:DiVA.org:uu-245321
003		SwePub
008		150226s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:129864897
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2453212 URI
024	7	a https://doi.org/10.4269/ajtmh.14-00312 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1298648972 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Venkatesan, Meera4 aut
245	1 0	a Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes :b parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.
264	1	b American Society of Tropical Medicine and Hygiene,c 2014
338		a print2 rdacarrier
520		a Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been clearly defined. Individual patient data from 31 clinical trials were harmonized and pooled by using standardized methods from the WorldWide Antimalarial Resistance Network. Data for more than 7,000 patients were analyzed to assess relationships between parasite polymorphisms in pfcrt and pfmdr1 and clinically relevant outcomes after treatment with AL or ASAQ. Presence of the pfmdr1 gene N86 (adjusted hazards ratio = 4.74, 95% confidence interval = 2.29 - 9.78, P < 0.001) and increased pfmdr1 copy number (adjusted hazards ratio = 6.52, 95% confidence interval = 2.36-17.97, P < 0.001 : were significant independent risk factors for recrudescence in patients treated with AL. AL and ASAQ exerted opposing selective effects on single-nucleotide polymorphisms in pfcrt and pfmdr1. Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine.
700	1	a Gadalla, Nahla B4 aut
700	1	a Stepniewska, Kasia4 aut
700	1	a Dahal, Prabin4 aut
700	1	a Nsanzabana, Christian4 aut
700	1	a Moriera, Clarissa4 aut
700	1	a Price, Ric N4 aut
700	1	a Mårtensson, Andreasu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut0 (Swepub:uu)andma331
700	1	a Rosenthal, Philip J4 aut
700	1	a Dorsey, Grant4 aut
700	1	a Sutherland, Colin J4 aut
700	1	a Guérin, Philippe4 aut
700	1	a Davis, Timothy M E4 aut
700	1	a Ménard, Didier4 aut
700	1	a Adam, Ishag4 aut
700	1	a Ademowo, George4 aut
700	1	a Arze, Cesar4 aut
700	1	a Baliraine, Frederick N4 aut
700	1	a Berens-Riha, Nicole4 aut
700	1	a Björkman, Andersu Karolinska Institutet4 aut
700	1	a Borrmann, Steffen4 aut
700	1	a Checchi, Francesco4 aut
700	1	a Desai, Meghna4 aut
700	1	a Dhorda, Mehul4 aut
700	1	a Djimdé, Abdoulaye A4 aut
700	1	a El-Sayed, Badria B4 aut
700	1	a Eshetu, Teferi4 aut
700	1	a Eyase, Frederick4 aut
700	1	a Falade, Catherine4 aut
700	1	a Faucher, Jean-François4 aut
700	1	a Fröberg, Gabrielleu Karolinska Institutet4 aut
700	1	a Grivoyannis, Anastasia4 aut
700	1	a Hamour, Sally4 aut
700	1	a Houzé, Sandrine4 aut
700	1	a Johnson, Jacobu Karolinska Institutet4 aut
700	1	a Kamugisha, Erasmus4 aut
700	1	a Kariuki, Simon4 aut
700	1	a Kiechel, Jean-René4 aut
700	1	a Kironde, Fred4 aut
700	1	a Kofoed, Poul-Erik4 aut
700	1	a LeBras, Jacques4 aut
700	1	a Malmberg, Maja4 aut
700	1	a Mwai, Leah4 aut
700	1	a Ngasala, Billy4 aut
700	1	a Nosten, Francois4 aut
700	1	a Nsobya, Samuel L4 aut
700	1	a Nzila, Alexis4 aut
700	1	a Oguike, Mary4 aut
700	1	a Otienoburu, Sabina Dahlström4 aut
700	1	a Ogutu, Bernhards4 aut
700	1	a Ouédraogo, Jean-Bosco4 aut
700	1	a Piola, Patrice4 aut
700	1	a Rombo, Larsu Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut0 (Swepub:uu)larra728
700	1	a Schramm, Birgit4 aut
700	1	a Somé, A Fabrice4 aut
700	1	a Thwing, Julie4 aut
700	1	a Ursing, Johan4 aut
700	1	a Wong, Rina P M4 aut
700	1	a Zeynudin, Ahmed4 aut
700	1	a Zongo, Issaka4 aut
700	1	a Plowe, Christopher V4 aut
700	1	a Sibley, Carol Hopkins4 aut
710	2	a Uppsala universitetb Centrum för klinisk forskning i Sörmland (CKFD)4 org
773	0	t The American journal of tropical medicine and hygiened : American Society of Tropical Medicine and Hygieneg 91:4, s. 833-43q 91:4<833-43x 1476-1645x 0002-9637
856	4	u https://europepmc.org/articles/pmc4183414?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-245321
856	4 8	u https://doi.org/10.4269/ajtmh.14-0031
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:129864897

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