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Telmisartan to prev...
Telmisartan to prevent recurrent stroke and cardiovascular events
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- Yusuf, S. (author)
- Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada; Population Health Research Institute, McMaster University, Hamilton, ON, Canada; Population Health Research Institute, McMaster University, Hamilton, ON, Canada; dHamilton Health Sciences, Hamilton, ON, Canada
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- Diener, H. C. (author)
- University of Duisberg-Essen, Essen, Germany
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- Sacco, R. L. (author)
- Miller School of Medicine, University of Miami, Miami, United States,Clinical Trials Methodology Group, McMaster University, Hamilton, ON, Canada
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- Cotton, D. (author)
- Boehringer Ingelheim, Ridgefield, CT, United States
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Ounpuu, S. (author)
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Lawton, W. A. (author)
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- Palesch, Y. (author)
- Medical University, Soudi Carolina, Charleston, United States
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- Martin, R. H. (author)
- Medical University, Soudi Carolina, Charleston, United States
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- Albers, G. W. (author)
- Stanford University, Medical Center, Palo Alto, CA, United States
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- Bath, P. (author)
- University of Nottingham, Nottingham, United Kingdom
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- Bornstein, N. (author)
- Ichilov Medical Center, Tel-Aviv, Israel
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- Chan, B. P. (author)
- National University Hospital, Singapore, Singapore,St. Johns's Medical College, Bangalore, India
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- Chen, S. T. (author)
- Chang Gung Memorial Hospital, Tapei, Taiwan
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- Cunha, L. (author)
- Hospitais da Universidade de Coimbra, Coimbra, Portugal
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- Dahlöf, Björn, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,Sahlgrenska University Hospital, Östra, Göteborg, Sweden
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- De Keyser, J. (author)
- University Medical Center Groningen, Groningen, Netherlands
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- Donnan, G. A. (author)
- National Stroke Research Institute, Austin Health, University of Melbourne, Heidelberg West, Australia
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- Estol, C. (author)
- Neurological Center for Treatment and Research, Buenos Aires, Argentina
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- Gorelick, P. (author)
- University of Illinois, Chicago, United States
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Gu, V. (author)
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Hermansson, K. (author)
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- Hilbrich, L. (author)
- Boehringer Ingelheim, Ridgefield, CT, United States
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- Kaste, M. (author)
- Helsinki University, Central Hospital, Helsinki, Finland
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- Lu, C. (author)
- Huashan Hospital, Shanghai, China
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Machnig, T. (author)
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Pais, P. (author)
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Roberts, R. (author)
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- Skvortsova, V. (author)
- Russian State Medical University, Moscow, Russian Federation
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- Teal, P. (author)
- University of British Columbia, Vancouver, Canada
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- Toni, D. (author)
- University La Sapienza, Rome, Italy
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- VanderMaelen, C. (author)
- Boehringer Ingelheim, Ridgefield, CT, United States
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- Voigt, T. (author)
- Boehringer Ingelheim, Ridgefield, CT, United States
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- Weber, M. (author)
- Boehringer Ingelheim, Ridgefield, CT, United States
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- Yoon, B. W. (author)
- Seoul National University Hospital, Seoul, South Korea
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von Euler, Mia, 1967- (author)
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(creator_code:org_t)
- Massachusetts medical society, 2008
- 2008
- English.
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In: New England Journal of Medicine. - : Massachusetts medical society. - 1533-4406 .- 0028-4793. ; 359:12, s. 1225-37
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin-angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including stroke. However, the effect of lowering of blood pressure with a renin-angiotensin system inhibitor soon after a stroke has not been clearly established. We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke. METHODS: In a multicenter trial involving 20,332 patients who recently had an ischemic stroke, we randomly assigned 10,146 to receive telmisartan (80 mg daily) and 10,186 to receive placebo. The primary outcome was recurrent stroke. Secondary outcomes were major cardiovascular events (death from cardiovascular causes, recurrent stroke, myocardial infarction, or new or worsening heart failure) and new-onset diabetes. RESULTS: The median interval from stroke to randomization was 15 days. During a mean follow-up of 2.5 years, the mean blood pressure was 3.8/2.0 mm Hg lower in the telmisartan group than in the placebo group. A total of 880 patients (8.7%) in the telmisartan group and 934 patients (9.2%) in the placebo group had a subsequent stroke (hazard ratio in the telmisartan group, 0.95; 95% confidence interval [CI], 0.86 to 1.04; P=0.23). Major cardiovascular events occurred in 1367 patients (13.5%) in the telmisartan group and 1463 patients (14.4%) in the placebo group (hazard ratio, 0.94; 95% CI, 0.87 to 1.01; P=0.11). New-onset diabetes occurred in 1.7% of the telmisartan group and 2.1% of the placebo group (hazard ratio, 0.82; 95% CI, 0.65 to 1.04; P=0.10). CONCLUSIONS: Therapy with telmisartan initiated soon after an ischemic stroke and continued for 2.5 years did not significantly lower the rate of recurrent stroke, major cardiovascular events, or diabetes. (ClinicalTrials.gov number, NCT00153062.)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Aged
- Angiotensin-Converting Enzyme Inhibitors/adverse effects/*therapeutic use
- Benzimidazoles/adverse effects/*therapeutic use
- Benzoates/adverse effects/*therapeutic use
- Blood Pressure/drug effects
- Cardiovascular Diseases/epidemiology/mortality/*prevention & control
- Creatinine/blood
- Diabetes Mellitus/epidemiology
- Female
- Follow-Up Studies
- Heart Failure/epidemiology/prevention & control
- Humans
- Kaplan-Meiers Estimate
- Male
- Middle Aged
- Myocardial Infarction/epidemiology/prevention & control
- Potassium/blood
- Recurrence/prevention & control
- Stroke/*drug therapy/prevention & control
- Treatment Failure
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Yusuf, S.
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Diener, H. C.
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Sacco, R. L.
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Cotton, D.
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Ounpuu, S.
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Lawton, W. A.
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show more...
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Palesch, Y.
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Martin, R. H.
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Albers, G. W.
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Bath, P.
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Bornstein, N.
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Chan, B. P.
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Chen, S. T.
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Cunha, L.
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Dahlöf, Björn, 1 ...
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De Keyser, J.
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Donnan, G. A.
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Estol, C.
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Gorelick, P.
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Gu, V.
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Hermansson, K.
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Hilbrich, L.
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Kaste, M.
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Lu, C.
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Machnig, T.
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Pais, P.
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Roberts, R.
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Skvortsova, V.
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Teal, P.
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Toni, D.
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VanderMaelen, C.
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Voigt, T.
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Weber, M.
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Yoon, B. W.
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von Euler, Mia, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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New England Jour ...
- By the university
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University of Gothenburg
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Örebro University
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Karolinska Institutet