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Sökning: WFRF:(Dietrich M.) > Örebro universitet > Pre-clinical testin...

Pre-clinical testing of therapies for traumatic brain injury

DeWitt, Douglas S. (författare)
Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States
Hawkins, Bridget E. (författare)
Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States
Dixon, C. Edward (författare)
Department of Neurological Surgery, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
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Kochanek, Patrick M. (författare)
Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
Armstead, William (författare)
Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Bass, Cameron R. (författare)
Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States
Bramlett, Helen M. (författare)
Department of Neurological Surgery, The Miami Project to Cure Paralysis, Miami, Florida, United States
Büki, Andras, 1966- (författare)
Department of Neurosurgery, Medical University of Pécs, Pécs, Hungary
Dietrich, W. Dalton (författare)
The Miami Project to Cure Paralysis, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States
Ferguson, Adam R. (författare)
Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF), San Francisco, California, United States
Hall, Edward D. (författare)
Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky Medical Center, Lexington, Kentucky, United States
Hayes, Ronald L. (författare)
University of Florida, Virginia Commonwealth University, Banyan Biomarkers, Inc., Alachua, Florida, United States
Hinds, Sidney R. (författare)
United States Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States
LaPlaca, Michelle C. (författare)
Georgia Institute of Technology/Emory University, Atlanta, Georgia, United States
Long, Joseph B. (författare)
Blast-Induced Neurotrauma Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States
Meaney, David F. (författare)
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Mondello, Stefania (författare)
Department of Neurosciences, University of Messina, Via Consolare Valeria, Messina, Italy
Noble-Haeusslein, Linda J. (författare)
Departments of Neurology and Psychology, Dell Medical School, The University of Texas at Austin, Austin, Texas, United States
Poloyac, Samuel M. (författare)
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, United States
Prough, Donald S. (författare)
Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States
Robertson, Claudia S. (författare)
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, United States
Saatman, Kathryn E. (författare)
Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky, Lexington, Kentucky, United States
Shultz, Sandy R. (författare)
Department of Medicine, Melbourne Brain Center, The University of Melbourne, Parkville, Victoria, Australia
Shear, Deborah A. (författare)
Brain Trauma Neuroprotection Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States
Smith, Douglas H. (författare)
Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Valadka, Alex B. (författare)
Department of Neurosurgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States
VandeVord, Pamela (författare)
Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States
Zhang, Liying (författare)
Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, United States
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 (creator_code:org_t)
Mary Ann Liebert, 2018
2018
Engelska.
Ingår i: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 35:23, s. 2737-2754
Relaterad länk:
https://www.ncbi.nlm...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Despite the large number of promising neuroprotective agents identified in experimental traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long-term outcome in clinical trials. To develop recommendations and guidelines for pre-clinical testing of pharmacological or biological therapies for TBI, the Moody Project for Translational Traumatic Brain Injury Research hosted a symposium attended by investigators with extensive experience in pre-clinical TBI testing. The symposium participants discussed issues related to pre-clinical TBI testing including experimental models, therapy and outcome selection, study design, data analysis, and dissemination. Consensus recommendations included the creation of a manual of standard operating procedures with sufficiently detailed descriptions of modeling and outcome measurement procedures to permit replication. The importance of the selection of clinically relevant outcome variables, especially related to behavior testing, was noted. Considering the heterogeneous nature of human TBI, evidence of therapeutic efficacy in multiple, diverse (e.g., diffuse vs. focused) rodent models and a species with a gyrencephalic brain prior to clinical testing was encouraged. Basing drug doses, times, and routes of administration on pharmacokinetic and pharmacodynamic data in the test species was recommended. Symposium participants agreed that the publication of negative results would reduce costly and unnecessary duplication of unsuccessful experiments. Although some of the recommendations are more relevant to multi-center, multi-investigator collaborations, most are applicable to pre-clinical therapy testing in general. The goal of these consensus guidelines is to increase the likelihood that therapies that improve outcomes in pre-clinical studies will also improve outcomes in TBI patients. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Guidelines
pre-clinical
traumatic brain injury

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ref (ämneskategori)
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