Sökning: WFRF:(Eriksson Johanna) > Anti-neutrophil cyt...
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000 | 06233naa a2200709 4500 | |
001 | oai:DiVA.org:umu-212005 | |
003 | SwePub | |
008 | 230712s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-430235 | |
009 | oai:lup.lub.lu.se:b960c680-b45f-4e39-8da1-19692bc3297d | |
009 | oai:DiVA.org:liu-174141 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2120052 URI |
024 | 7 | a https://doi.org/10.1016/j.jaut.2020.1025792 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4302352 URI |
024 | 7 | a https://lup.lub.lu.se/record/b960c680-b45f-4e39-8da1-19692bc3297d2 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1741412 URI |
040 | a (SwePub)umud (SwePub)uud (SwePub)lud (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Berglin, Ewa,c MD, PhD,d 1955-u Umeå University,Umeå universitet,Reumatologi,Umea Univ, Sweden4 aut0 (Swepub:umu)evbe0009 |
245 | 1 0 | a Anti-neutrophil cytoplasmic antibodies predate symptom onset of ANCA-associated vasculitis :b a case-control study |
264 | 1 | b Elsevier,c 2021 |
338 | a electronic2 rdacarrier | |
500 | a Funding Agencies|Vasculitis foundation USA; Swedish Research CouncilSwedish Research CouncilEuropean Commission [K2013-52X-20307-07-3, 2018-02551]; King Gustaf Vs 80-Year Fund; Swedish Rheumatism Association; Umea University | |
520 | a Objectives: Anti-neutrophil cytoplasmic autoantibodies [ANCA) are important for diagnosis of ANCA-associated vasculitides (AAV). The timing of antibody development is not well established. To investigate the development of proteinase 3 (PR3)- and myeloperoxidase (MPO)-ANCA, blood samples collected before onset of symptoms of AAV were analysed.Methods: To identify AAV patients with blood samples predating symptoms, the National Patient Register and Cause of Death register were scrutinized for ICD codes for AAV and linked to the registers of five biobanks. Diagnoses of AAV and time point for symptom onset were confirmed by reviewing 504 case-record. Eighty-five AAV cases (34 males, 51 females) with samples >1 month < 10 years from AAV symptom onset and two controls matched for sex, age, and sampling time for each case were included. Samples were screened using ELISAs for ANCA and further analysed for PR3-or MPO- specificities.Results: In ANCA-screen 35.7% of the pre-symptomatic cases and 3.5% of controls tested positive (p < 0.01). 26.2% of the cases were PR3-ANCA+ and 10.7% MPO-ANCA+. Median (Q1-Q3) predating time for PR3-ANCA+ was 2.7 (0.3–7.7) years and MPO-ANCA+ 2.0 (0.9–3.5) years. PR3-ANCA was demonstrated in samples up to nine years before symptom onset. At symptom onset predating PR3-ANCA+ cases were younger than PR3-ANCA- (P < 0.01), and MPO-ANCA+ were older than MPO-ANCA- (p < 0.05). Predating MPO-ANCA+ cases vs. MPO-ANCA- and vs. PR3-ANCA+ cases had more often at symptoms onset manifestations from lungs, kidneys or peripheral nervous system (p < 0.01 and p < 0.05, respectively).Conclusion: The PR3-and MPO-ANCAs are present years before AAV symptom onset and represent distinct diseases. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
653 | a AAV | |
653 | a GPA | |
653 | a MPA | |
653 | a MPO-ANCA | |
653 | a PR3-ANCA | |
653 | a Predate symptom onset | |
653 | a AAV | |
653 | a GPA | |
653 | a MPA | |
653 | a MPO-ANCA | |
653 | a PR3-ANCA | |
653 | a Predate symptom onset | |
700 | 1 | a Mohammad, Aladdin J.u Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Cambridge,Lund Univ, Sweden; Univ Cambridge, England4 aut0 (Swepub:lu)reum-amo |
700 | 1 | a Dahlqvist, Johanna,d 1979-u Uppsala University,Uppsala universitet,Reumatologi,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Sweden4 aut0 (Swepub:uu)johda205 |
700 | 1 | a Johansson, Lindau Umeå University,Umeå universitet,Reumatologi,Umea Univ, Sweden4 aut0 (Swepub:umu)lijo0115 |
700 | 1 | a Eriksson, Catharina,d 1955-u Umeå University,Umeå universitet,Klinisk immunologi,Umea Univ, Sweden4 aut0 (Swepub:umu)caaern74 |
700 | 1 | a Sjöwall, Johannau Linköpings universitet,Linköping University,Linköping University Hospital,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland4 aut0 (Swepub:liu)johfo45 |
700 | 1 | a Rantapää-Dahlqvist, Solbrittu Umeå University,Umeå universitet,Reumatologi,Umea Univ, Sweden4 aut0 (Swepub:umu)sora0001 |
710 | 2 | a Umeå universitetb Reumatologi4 org |
773 | 0 | t Journal of Autoimmunityd : Elsevierg 117q 117x 0896-8411x 1095-9157 |
856 | 4 | u https://doi.org/10.1016/j.jaut.2020.102579y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1782052/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.jaut.2020.102579 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1515192/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1016/j.jaut.2020.102579x freey FULLTEXT |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1537230/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212005 |
856 | 4 8 | u https://doi.org/10.1016/j.jaut.2020.102579 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430235 |
856 | 4 8 | u https://lup.lub.lu.se/record/b960c680-b45f-4e39-8da1-19692bc3297d |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174141 |
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