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Sökning: WFRF:(Forgetta Vincenzo) > Dehydration is asso...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005851naa a2200577 4500
001oai:DiVA.org:uu-487057
003SwePub
008221023s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4870572 URI
0247 a https://doi.org/10.1186/s13054-022-04203-w2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hultström, Michael,d 1978-u Uppsala universitet,Anestesiologi och intensivvård,Integrativ Fysiologi,Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.;Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut0 (Swepub:uu)mihul498
2451 0a Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19 :b a multicenter cohort study
264 c 2022-10-21
264 1b Springer Nature,c 2022
338 a electronic2 rdacarrier
520 a BACKGROUND: We have previously shown that iatrogenic dehydration is associated with a shift to organic osmolyte production in the general ICU population. The aim of the present investigation was to determine the validity of the physiological response to dehydration known as aestivation and its relevance for long-term disease outcome in COVID-19.METHODS: The study includes 374 COVID-19 patients from the Pronmed cohort admitted to the ICU at Uppsala University Hospital. Dehydration data was available for 165 of these patients and used for the primary analysis. Validation was performed in Biobanque Québécoise de la COVID-19 (BQC19) using 1052 patients with dehydration data. Dehydration was assessed through estimated osmolality (eOSM = 2Na + 2 K + glucose + urea), and correlated to important endpoints including death, invasive mechanical ventilation, acute kidney injury, and long COVID-19 symptom score grouped by physical or mental.RESULTS: Increasing eOSM was correlated with increasing role of organic osmolytes for eOSM, while the proportion of sodium and potassium of eOSM were inversely correlated to eOSM. Acute outcomes were associated with pronounced dehydration, and physical long-COVID was more strongly associated with dehydration than mental long-COVID after adjustment for age, sex, and disease severity. Metabolomic analysis showed enrichment of amino acids among metabolites that showed an aestivating pattern.CONCLUSIONS: Dehydration during acute COVID-19 infection causes an aestivation response that is associated with protein degradation and physical long-COVID.TRIAL REGISTRATION: The study was registered à priori (clinicaltrials.gov: NCT04316884 registered on 2020-03-13 and NCT04474249 registered on 2020-06-29).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
653 a Acute kidney injury
653 a Aestivation
653 a Intensive care medicine
653 a Long-COVID
653 a SARS-CoV-2
653 a Urea synthesis
7001 a Lipcsey, Miklósu Uppsala universitet,Hedenstiernalaboratoriet4 aut0 (Swepub:uu)milip123
7001 a Morrison, Dave Ru Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut
7001 a Nakanishi, Tomokou Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut
7001 a Butler-Laporte, Guillaumeu Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut
7001 a Chen, Yihengu Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut
7001 a Yoshiji, Satoshiu Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut
7001 a Forgetta, Vincenzou Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut
7001 a Farjoun, Yossiu Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut
7001 a Wallin, Ewau Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)ewawa635
7001 a Larsson, Ing-Marie,d 1963-u Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)ingla697
7001 a Larsson, Andersu Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)andlarss
7001 a Marton, Adrianau Program in Cardiovascular and Metabolic Disorders, Duke- NUS Medical School, Singapore, Singapore.4 aut
7001 a Titze, Jens Marcu Program in Cardiovascular and Metabolic Disorders, Duke- NUS Medical School, Singapore, Singapore.4 aut
7001 a Nihlén, Sandrau Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)sanho907
7001 a Richards, J Brentu Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.4 aut
7001 a Frithiof, Robertu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)robfr118
7102 a Uppsala universitetb Anestesiologi och intensivvård4 org
7730 t Critical Cared : Springer Natureg 26q 26x 1364-8535x 1466-609X
8564 u https://doi.org/10.1186/s13054-022-04203-wy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1705422/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-487057
8564 8u https://doi.org/10.1186/s13054-022-04203-w

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