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Precision cancer me...
Precision cancer medicine : Concepts, current practice, and future developments
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- Edsjö, Anders (författare)
- Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Genomic Medicine Sweden (GMS),Region Skåne
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- Holmquist, Louise (författare)
- Region Skåne,Genomic Medicine Sweden (GMS)
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- Geoerger, Birgit (författare)
- Institut Gustave Roussy
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- Nowak, Frédérique (författare)
- National Institute for Health and Medical Research, France
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- Gomon, Georgy (författare)
- Leiden University Medical Centre,Antoni Van Leeuwenhoek Hospital
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- Alix-Panabières, Catherine (författare)
- University of Montpellier,Montpellier University Hospital
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- Ploeger, Carolin (författare)
- University Hospital Heidelberg
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- Lassen, Ulrik (författare)
- Copenhagen University Hospital
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- Le Tourneau, Christophe (författare)
- National Institute for Health and Medical Research, France,Curie Institute, Paris,University of Paris-Saclay
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- Lehtiö, Janne (författare)
- Karolinska Institutet,Science for Life Laboratory (SciLifeLab)
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- Ott, Patrick A. (författare)
- Dana-Farber Cancer Institute,Princess Margaret Hospital University of Toronto
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- von Deimling, Andreas (författare)
- University Hospital Heidelberg,German Cancer Research Centre
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- Fröhling, Stefan (författare)
- German Cancer Research Centre
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- Voest, Emile (författare)
- Antoni Van Leeuwenhoek Hospital
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- Klauschen, Frederick (författare)
- German Cancer Research Centre,Ludwig-Maximilian University of Munich,Charité - University Medicine Berlin
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Dienstmann, Rodrigo (författare)
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- Alshibany, Aisha (författare)
- Princess Margaret Hospital University of Toronto
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- Siu, Lillian L. (författare)
- Princess Margaret Hospital University of Toronto
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- Stenzinger, Albrecht (författare)
- University Hospital Heidelberg
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(creator_code:org_t)
- 2023
- 2023
- Engelska 27 s.
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Ingår i: Journal of Internal Medicine. - 0954-6820 .- 1365-2796. ; 294:4, s. 455-481
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Precision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological patients over the last two decades, future developments will be significantly shaped by improvements in scalable molecular diagnostics in which increasingly complex multilayered datasets require transformation into clinically useful information guiding patient management at fast turnaround times. Adaptive profiling strategies involving tissue- and liquid-based testing that account for the immense plasticity of cancer during the patient's journey and also include early detection approaches are already finding their way into clinical routine and will become paramount. A second major driver is the development of smart clinical trials and trial concepts which, complemented by real-world evidence, rapidly broaden the spectrum of therapeutic options. Tight coordination with regulatory agencies and health technology assessment bodies is crucial in this context. Multicentric networks operating nationally and internationally are key in implementing precision oncology in clinical practice and support developing and improving the ecosystem and framework needed to turn invocation into benefits for patients. The review provides an overview of the diagnostic tools, innovative clinical studies, and collaborative efforts needed to realize precision cancer medicine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- clinical trials
- molecular diagnostics
- personalized oncology
- precision cancer medicine
- precision medicine networks
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- Av författaren/redakt...
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Edsjö, Anders
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Holmquist, Louis ...
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Geoerger, Birgit
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Nowak, Frédériqu ...
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Gomon, Georgy
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Alix-Panabières, ...
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visa fler...
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Ploeger, Carolin
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Lassen, Ulrik
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Le Tourneau, Chr ...
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Lehtiö, Janne
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Ott, Patrick A.
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von Deimling, An ...
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Fröhling, Stefan
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Voest, Emile
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Klauschen, Frede ...
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Dienstmann, Rodr ...
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Alshibany, Aisha
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Siu, Lillian L.
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Stenzinger, Albr ...
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Lunds universitet
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Karolinska Institutet