WFRF:(Gatto Francesco 1987)
Sökning: WFRF:(Gatto Francesco 1987) > (2020) > Meta-analysis of th...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04572naa a2200493 4500 | |
| 001 | oai:gup.ub.gu.se/299065 | |
| 003 | SwePub | |
| 008 | 240528s2020 | |||||||||||000 ||eng| | |
| 009 | oai:research.chalmers.se:c19f1472-90bb-4c64-8f6d-512e9e10b540 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2990652 URI |
| 024 | 7 | a https://doi.org/10.1172/jci.insight.1409402 DOI |
| 024 | 7 | a https://research.chalmers.se/publication/5210512 URI |
| 040 | a (SwePub)gud (SwePub)cth | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Limeta, Angelo,d 1996u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)angelol |
| 245 | 1 0 | a Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma. |
| 264 | c 2020-12-03 | |
| 264 | 1 | b American Society for Clinical Investigation,c 2020 |
| 520 | a BACKGROUNDIdentifying factors conferring responses to therapy in cancer is critical to select the best treatment for patients. For immune checkpoint inhibition (ICI) therapy, mounting evidence suggests that the gut microbiome can determine patient treatment outcomes. However, the extent to which gut microbial features are applicable across different patient cohorts has not been extensively explored.METHODSWe performed a meta-analysis of 4 published shotgun metagenomic studies (Ntot = 130 patients) investigating differential microbiome composition and imputed metabolic function between responders and nonresponders to ICI.RESULTSOur analysis identified both known microbial features enriched in responders, such as Faecalibacterium as the prevailing taxa, as well as additional features, including overrepresentation of Barnesiella intestinihominis and the components of vitamin B metabolism. A classifier designed to predict responders based on these features identified responders in an independent cohort of 27 patients with the area under the receiver operating characteristic curve of 0.625 (95% CI: 0.348-0.899) and was predictive of prognosis (HR = 0.35, P = 0.081).CONCLUSIONThese results suggest the existence of a fecal microbiome signature inherent across responders that may be exploited for diagnostic or therapeutic purposes.FUNDINGThis work was funded by the Knut and Alice Wallenberg Foundation, BioGaia AB, and Cancerfonden. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
| 653 | a immunotherapy | |
| 653 | a melanoma | |
| 653 | a cancer | |
| 653 | a oncology | |
| 653 | a onkologi | |
| 700 | 1 | a Ji, Boyang,d 1983u Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)bojand |
| 700 | 1 | a Levin, Max,d 1969u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Wallenberg Laboratory,Institute of Clinical Sciences, Department of Oncology,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg4 aut0 (Swepub:gu)xlevma |
| 700 | 1 | a Gatto, Francesco,d 1987u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)gatto |
| 700 | 1 | a Nielsen, Jens B,d 1962u Chalmers tekniska högskola,Chalmers University of Technology,BioInnovation Institute (BII),Danmarks Tekniske Universitet,Technical University of Denmark4 aut0 (Swepub:cth)nielsenj |
| 710 | 2 | a Chalmers tekniska högskolab Danmarks Tekniske Universitet4 org |
| 773 | 0 | t JCI insightd : American Society for Clinical Investigationg 5:23q 5:23x 2379-3708 |
| 856 | 4 | u http://insight.jci.org/articles/view/140940/files/pdf |
| 856 | 4 | u https://research.chalmers.se/publication/521051/file/521051_Fulltext.pdfx primaryx freey FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/299065 |
| 856 | 4 8 | u https://doi.org/10.1172/jci.insight.140940 |
| 856 | 4 8 | u https://research.chalmers.se/publication/521051 |
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