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Double-negative B c...
Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue
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- Montorsi, Lucia (author)
- King's College London
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- Pitcher, Michael J (author)
- King's College London
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- Zhao, Yuan (author)
- King's College London
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- Dionisi, Chiara (author)
- King's College London
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- Demonti, Alicia (author)
- King's College London
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- Tull, Thomas J (author)
- King's College London
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Dhami, Pawan (author)
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Ellis, Richard J (author)
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Bishop, Cynthia (author)
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- Sanderson, Jeremy D (author)
- King's College London
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Jain, Sahil (author)
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- D'Cruz, David (author)
- King's College London
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- Gibbons, Deena L (author)
- King's College London
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- Winkler, Thomas H (author)
- Friedrich-Alexander University Erlangen-Nürnberg
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- Bemark, Mats (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lärare vid läkarprogrammet,Avdelningen för läkarprogrammets kursadministration,Utbildningsenheten,Kansli M,Medicinska fakulteten,Immunology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Teachers at the Medical Programme,Division of Course Administration for the Medical Programme,The Education Office,Faculty Office - BMC,Faculty of Medicine,Sahlgrenska University Hospital
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- Ciccarelli, Francesca D (author)
- Francis Crick Institute
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- Spencer, Jo (author)
- King's College London
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Nature Communications. - 2041-1723. ; 15:1, s. 4051-4051
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Intestinal homeostasis is maintained by the response of gut-associated lymphoid tissue to bacteria transported across the follicle associated epithelium into the subepithelial dome. The initial response to antigens and how bacteria are handled is incompletely understood. By iterative application of spatial transcriptomics and multiplexed single-cell technologies, we identify that the double negative 2 subset of B cells, previously associated with autoimmune diseases, is present in the subepithelial dome in health. We show that in this location double negative 2 B cells interact with dendritic cells co-expressing the lupus autoantigens DNASE1L3 and C1q and microbicides. We observe that in humans, but not in mice, dendritic cells expressing DNASE1L3 are associated with sampled bacteria but not DNA derived from apoptotic cells. We propose that fundamental features of autoimmune diseases are microbiota-associated, interacting components of normal intestinal immunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Animals
- Humans
- Mice
- B-Lymphocytes/immunology
- Gastrointestinal Microbiome/immunology
- Endodeoxyribonucleases/metabolism
- Dendritic Cells/immunology
- Lymphoid Tissue/immunology
- Female
- Mice, Inbred C57BL
- Intestinal Mucosa/immunology
- Male
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Montorsi, Lucia
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Pitcher, Michael ...
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Zhao, Yuan
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Dionisi, Chiara
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Demonti, Alicia
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Tull, Thomas J
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show more...
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Dhami, Pawan
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Ellis, Richard J
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Bishop, Cynthia
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Sanderson, Jerem ...
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Jain, Sahil
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D'Cruz, David
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Gibbons, Deena L
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Winkler, Thomas ...
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Bemark, Mats
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Ciccarelli, Fran ...
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Spencer, Jo
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University