Impaired Myofibrillar Function in the Soleus Muscle of Mice With Collagen-Induced Arthritis

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Fältnamn	Indikatorer	Metadata
000		04048naa a2200481 4500
001		oai:DiVA.org:kth-33118
003		SwePub
008		110428s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:119595053
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-331182 URI
024	7	a https://doi.org/10.1002/art.249072 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1195950532 URI
040		a (SwePub)kthd (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Yamada, Takashi4 aut
245	1 0	a Impaired Myofibrillar Function in the Soleus Muscle of Mice With Collagen-Induced Arthritis
264		c 2009-10-29
264	1	b Wiley,c 2009
338		a print2 rdacarrier
500		a QC 20110428
520		a Objective. Progressive muscle weakness is a common feature in patients with rheumatoid arthritis (RA). However, little is known about whether the intrinsic contractile properties of muscle fibers are affected in RA. This study was undertaken to investigate muscle contractility and the myoplasmic free Ca2+ concentration ([Ca2+](i)) in the soleus, a major postural muscle, in mice with collagen-induced arthritis (CIA). Methods. Muscle contractility and [Ca2+](i) were assessed in whole muscle and intact single-fiber preparations, respectively. The underlying mechanisms of contractile dysfunction were assessed by investigating redox modifications using Western blotting and antibodies against nitric oxide synthase (NOS), superoxide dismutase (SOD), 3-nitrotyrosine (3-NT), carbonyl, malondialdehyde (MDA), and S-nitrosocysteine (SNO-Cys). Results. The tetanic force per cross-sectional area was markedly decreased in the soleus muscle of mice with CIA, and the change was not due to a decrease in the amplitude of [Ca2+](i) transients. The reduction in force production was accompanied by slowing of the twitch contraction and relaxation and a decrease in the maximum shortening velocity. Immunoblot analyses showed a marked increase in neuronal NOS expression but not in inducible or endothelial NOS expression, which, together with the observed decrease in SOD2 expression, favors peroxynitrite formation. These changes were accompanied by increased 3-NT, carbonyl, and MDA adducts content in myofibrillar proteins from the muscles of mice with CIA. Moreover, there was a significant increase in SNO-Cys content in myosin heavy-chain and troponin I myofibrillar proteins from the soleus muscle of mice with CIA. Conclusion. These findings show impaired contractile function in the soleus muscle of mice with CIA and suggest that this abnormality is due to peroxynitrite-induced modifications in myofibrillar proteins.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653		a Rheumatology
653		a Reumatologi
700	1	a Place, Nicolas4 aut
700	1	a Kosterina, Nataliau KTH,Strukturmekanik4 aut0 (Swepub:kth)u1eii1l7
700	1	a Östberg, Thereseu Karolinska Institutet4 aut
700	1	a Zhang, Shi-Jinu Karolinska Institutet4 aut
700	1	a Grundtman, Ceciliau Karolinska Institutet4 aut
700	1	a Erlandsson-Harris, Helenau Karolinska Institutet4 aut
700	1	a Lundberg, Ingrid E.u Karolinska Institutet4 aut
700	1	a Glenmark, Birgittau Karolinska Institutet4 aut
700	1	a Bruton, Joseph D.u Karolinska Institutet4 aut
700	1	a Westerblad, Hakanu Karolinska Institutet4 aut
710	2	a KTHb Strukturmekanik4 org
773	0	t Arthritis and Rheumatismd : Wileyg 60:11, s. 3280-3289q 60:11<3280-3289x 0004-3591x 1529-0131
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-33118
856	4 8	u https://doi.org/10.1002/art.24907
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:119595053

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Av författaren/redakt...: Yamada, Takashi; Place, Nicolas; Kosterina, Natal ...; Östberg, Therese; Zhang, Shi-Jin; Grundtman, Cecil ...; visa fler...; Erlandsson-Harri ...; Lundberg, Ingrid ...; Glenmark, Birgit ...; Bruton, Joseph D ...; Westerblad, Haka ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

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