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Sökning: onr:"swepub:oai:DiVA.org:uu-420893" > Fatty acids in the ...

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FältnamnIndikatorerMetadata
00011041naa a2200937 4500
001oai:DiVA.org:uu-420893
003SwePub
008201002s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4208932 URI
0247 a https://doi.org/10.1371/journal.pmed.10031022 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Imamura, Fumiakiu Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
2451 0a Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes :b A pooled analysis of prospective cohort studies
264 c 2020-06-12
264 1b Public Library of Science (PLoS),c 2020
338 a electronic2 rdacarrier
520 a BackgroundDe novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL with incidence of type 2 diabetes (T2D).Methods and findingsSeventeen cohorts from 12 countries (7 from Europe, 7 from the United States, 1 from Australia, 1 from Taiwan; baseline years = 1970–1973 to 2006–2010) conducted harmonized individual-level analyses of associations of DNL-related fatty acids with incident T2D. In total, we evaluated 65,225 participants (mean ages = 52.3–75.5 years; % women = 20.4%–62.3% in 12 cohorts recruiting both sexes) and 15,383 incident cases of T2D over the 9-year follow-up on average. Cohort-specific association of each of 16:0, 16:1n7, 18:0, and 18:1n9 with incident T2D was estimated, adjusted for demographic factors, socioeconomic characteristics, alcohol, smoking, physical activity, dyslipidemia, hypertension, menopausal status, and adiposity. Cohort-specific associations were meta-analyzed with an inverse-variance-weighted approach. Each of the 4 fatty acids positively related to incident T2D. Relative risks (RRs) per cohort-specific range between midpoints of the top and bottom quintiles of fatty acid concentrations were 1.53 (1.41–1.66; p < 0.001) for 16:0, 1.40 (1.33–1.48; p < 0.001) for 16:1n-7, 1.14 (1.05–1.22; p = 0.001) for 18:0, and 1.16 (1.07–1.25; p < 0.001) for 18:1n9. Heterogeneity was seen across cohorts (I2 = 51.1%–73.1% for each fatty acid) but not explained by lipid fractions and global geographical regions. Further adjusted for triglycerides (and 16:0 when appropriate) to evaluate associations independent of overall DNL, the associations remained significant for 16:0, 16:1n7, and 18:0 but were attenuated for 18:1n9 (RR = 1.03, 95% confidence interval (CI) = 0.94–1.13). These findings had limitations in potential reverse causation and residual confounding by imprecisely measured or unmeasured factors.ConclusionsConcentrations of fatty acids in the DNL were positively associated with T2D incidence. Our findings support further work to investigate a possible role of DNL and individual fatty acids in the development of T2D.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Fretts, Amanda M.u Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.4 aut
7001 a Marklund, Mattiu Uppsala universitet,Klinisk nutrition och metabolism,Univ New South Wales, George Inst Global Hlth, Fac Med, Sydney, NSW, Australia.;Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.4 aut0 (Swepub:uu)matma701
7001 a Ardisson Korat, Andres V.u Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
7001 a Yang, Wei-Sinu Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.4 aut
7001 a Lankinen, Mariau Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut
7001 a Qureshi, Waqasu Wake Forest Univ, Sch Med, Dept Internal Med, Sect Cardiovasc Med, Winston Salem, NC 27101 USA.4 aut
7001 a Helmer, Catherineu Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.4 aut
7001 a Chen, Tzu-Anu USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Baylor Coll Med, Houston, TX USA.4 aut
7001 a Virtanen, Jyrki K.u Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut
7001 a Wong, Kerryu Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.4 aut
7001 a Bassett, Julie K.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.4 aut
7001 a Murphy, Rachelu Univ British Columbia, Sch Populat Publ & Hlth, Ctr Excellence Canc Prevent, Fac Med, Vancouver, BC, Canada.4 aut
7001 a Tintle, Nathanu Dordt Univ, Dept Math & Stat, Sioux Ctr, IA USA.4 aut
7001 a Yu, Chaoyu Ianu Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA.4 aut
7001 a Brouwer, Ingeborg A.u Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Fac Sci, Amsterdam, Netherlands.4 aut
7001 a Chien, Kuo-Liongu Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.;Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan.4 aut
7001 a Chen, Yun-yuu Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.;Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan.4 aut
7001 a Wood, Alexis C.u USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Baylor Coll Med, Houston, TX USA.4 aut
7001 a del Gobbo, Liana C.u Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.4 aut
7001 a Djousse, Lucu Harvard Med Sch, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, 75 Francis St, Boston, MA 02115 USA.4 aut
7001 a Geleijnse, Johanna M.u Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.4 aut
7001 a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.4 aut
7001 a de Goede, Janetteu Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.4 aut
7001 a Gudnason, Vilmunduru Iceland Heart Assoc Res Inst, Kopavogur, Iceland.4 aut
7001 a Harris, William S.u Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.;OmegaQuant Analyt, Sioux Falls, SD USA.4 aut
7001 a Hodge, Allisonu Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.4 aut
7001 a Hu, Franku Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
7001 a Koulman, Albertu Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.;Univ Cambridge, Natl Inst Hlth Res, Addenbrookes Hosp, Biomed Res Ctr,Core Nutr Biomarker Lab, Cambridge, England.;Univ Cambridge, Natl Inst Hlth Res, Addenbrookes Hosp, Biomed Res Ctr,Core Metabol & Lipid Lab, Cambridge, England.;MRC, Elsie Widdowson Lab, Cambridge, England.4 aut
7001 a Laakso, Markkuu Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Med, Kuopio, Finland.4 aut
7001 a Lind, Larsu Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind
7001 a Lin, Hung-Juu Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.4 aut
7001 a McKnight, Barbarau Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA.4 aut
7001 a Rajaobelina, Kalinau Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.4 aut
7001 a Risérus, Ulf,d 1967-u Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser
7001 a Robinson, Jennifer G.u Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Prevent Intervent Ctr, Iowa City, IA USA.4 aut
7001 a Samieri, Ceciliau Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.4 aut
7001 a Senn, Mackenzieu USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Baylor Coll Med, Houston, TX USA.4 aut
7001 a Siscovick, David S.u New York Acad Med, New York, NY USA.4 aut
7001 a Soedamah-Muthu, Sabita S.u Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.;Tilburg Univ, Dept Med & Clin Psychol, Ctr Res Psychol & Somat Disorders, Tilburg, Netherlands.;Univ Reading, Inst Food Nutr & Hlth, Reading, Berks, England.4 aut
7001 a Sotoodehnia, Nonau Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.4 aut
7001 a Sun, Qiu Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
7001 a Tsai, Michael Y.u Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.4 aut
7001 a Tuomainen, Tomi-Pekkau Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut
7001 a Uusitupa, Mattiu Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut
7001 a Wagenknecht, Lynne E.u Wake Forest Sch Med, Publ Hlth Sci, Winston Salem, NC 27101 USA.4 aut
7001 a Wareham, Nick J.u Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
7001 a Wu, Jason H. Y.u Univ New South Wales, George Inst Global Hlth, Fac Med, Sydney, NSW, Australia.4 aut
7001 a Micha, Renatau Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.4 aut
7001 a Lemaitre, Rozenn N.u Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.4 aut
7001 a Mozaffarian, Dariushu Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.4 aut
7001 a Forouhi, Nita G.u Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
7102 a Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.b Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.4 org
7730 t PLoS Medicined : Public Library of Science (PLoS)g 17:6q 17:6x 1549-1277x 1549-1676
8564 u https://doi.org/10.1371/journal.pmed.1003102y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1472630/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003102&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420893
8564 8u https://doi.org/10.1371/journal.pmed.1003102

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