Sökning: WFRF:(Golka Klaus) > Pooled analysis and...
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000 | 03877naa a2200505 4500 | |
001 | oai:lup.lub.lu.se:82e26dcd-3702-4fd0-a2d3-dd463954e289 | |
003 | SwePub | |
008 | 160401s2007 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/6512122 URI |
024 | 7 | a https://doi.org/10.1093/aje/kwm0032 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a for2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Kellen, Eliane4 aut |
245 | 1 0 | a Pooled analysis and meta-analysis of the glutathione S-transferase P1 lle 105Val polymorphism and bladder cancer: A HuGE-GSEC review |
264 | c 2007-04-02 | |
264 | 1 | b Oxford University Press (OUP),c 2007 |
520 | a The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1lle 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 lle/Val and Val/Val compared with GSTP1 lle/lle were 1.54 (95% confidence interval: 1.21,1.99; p < 0.001) and 2.17 (95% confidence interval: 1.27, 3.71; p = 0.005). The association appeared to be the strongest in Asian countries. When the analysis was limited to European descendents (nine studies), the summary odds ratio decreased (odds ratio = 1.24, 95% confidence interval: 1.00, 1.52) (Q = 17.50; p = 0.02). All relevant data previously contributed to the International Study on Genetic Susceptibility to Environmental Carcinogens were pooled (eight studies, 1,305 cases and 1,558 controls). The summary odds ratios were similar to the ones from the meta-analysis. Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 lle 105Val appears to be associated with a modest increase in the risk of bladder cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a urinary bladder neoplasms | |
653 | a GSTP1 | |
653 | a meta-analysis | |
700 | 1 | a Hemelt, Marjolein4 aut |
700 | 1 | a Broberg Palmgren, Karinu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-kbr |
700 | 1 | a Golka, Klaus4 aut |
700 | 1 | a Kristensen, Vessela Nedelcheva4 aut |
700 | 1 | a Hung, Rayjean J.4 aut |
700 | 1 | a Matullo, Giuseppe4 aut |
700 | 1 | a Mittal, Rama D.4 aut |
700 | 1 | a Porru, Stefano4 aut |
700 | 1 | a Povey, Andrew4 aut |
700 | 1 | a Schulz, Wolfgang A.4 aut |
700 | 1 | a Shen, Jianhua4 aut |
700 | 1 | a Buntinx, Frank4 aut |
700 | 1 | a Zeegers, Maurice P.4 aut |
700 | 1 | a Taioli, Emanuela4 aut |
710 | 2 | a Avdelningen för arbets- och miljömedicinb Institutionen för laboratoriemedicin4 org |
773 | 0 | t American Journal of Epidemiologyd : Oxford University Press (OUP)g 165:11, s. 1221-1230q 165:11<1221-1230x 0002-9262x 1476-6256 |
856 | 4 | u http://dx.doi.org/10.1093/aje/kwm003x freey FULLTEXT |
856 | 4 | u https://academic.oup.com/aje/article-pdf/165/11/1221/204069/kwm003.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/651212 |
856 | 4 8 | u https://doi.org/10.1093/aje/kwm003 |
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