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Sökning: onr:"swepub:oai:lup.lub.lu.se:8e876198-93d8-46ff-8e67-70e085287ac7" > C-12 vs C-3 substit...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004317naa a2200469 4500
001oai:lup.lub.lu.se:8e876198-93d8-46ff-8e67-70e085287ac7
003SwePub
008191115s2020 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/8e876198-93d8-46ff-8e67-70e085287ac72 URI
0247 a https://doi.org/10.1016/j.colsurfb.2019.1105562 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Cautela, Jacopou Sapienza University of Rome4 aut
2451 0a C-12 vs C-3 substituted bile salts : An example of the effects of substituent position and orientation on the self-assembly of steroid surfactant isomers
264 1b Elsevier BV,c 2020
520 a Biomolecule derivatives are transversally used in nanotechnology. Deciphering their aggregation behavior is a crucial issue for the rational design of functional materials. To this end, it is necessary to build libraries of selectively functionalized analogues and infer general rules. In this work we enrich the highly applicative oriented collection of steroid derivatives, by reporting a rare example of C-12 selectively modified bile salt. While nature often exploits such position to encode functions, it is unusual and not trivial to prepare similar analogues in the laboratory. The introduction of a tert-butyl phenyl residue at C-12 provided a molecule with a self-assembly that remarkably switched from rigid pole-like structures to twisted ribbons at a biologically relevant critical temperature (∼25 °C). The system was characterized by microscopy and spectroscopy techniques and compared with the C-3 functionalized analogue. The twisted ribbons generate samples with a gel texture and a viscoelastic response. The parallel analysis of the two systems suggested that the observed thermoresponsive self-assemblies occur at similar critical temperatures and are probably dictated by the nature of the substituent, but involve aggregates with different structures depending on position and orientation of the substituent. This study highlights the self-assembly properties of two appealing thermoresponsive systems. Moreover, it adds fundamental insights hereto missing in the investigations of the relation between self-assembly and structure of synthetic steroids, which are valuable for the rational design of steroidal amphiphiles.
650 7a NATURVETENSKAPx Kemix Materialkemi0 (SwePub)104032 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Materials Chemistry0 (SwePub)104032 hsv//eng
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a Bile acid
653 a Hydrogel
653 a Steroid derivatives
653 a Thermoresponsive self-assembly
7001 a Severoni, Emiliau Sapienza University of Rome4 aut
7001 a Redondo-Gómez, Carlosu University of Costa Rica4 aut
7001 a di Gregorio, Maria Chiarau Sapienza University of Rome4 aut
7001 a Del Giudice, Alessandrau Sapienza University of Rome4 aut
7001 a Sennato, Simonau Sapienza University of Rome4 aut
7001 a Angelini, Robertau Sapienza University of Rome4 aut
7001 a D'Abramo, Marcou Sapienza University of Rome4 aut
7001 a Schillén, Karinu Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)fk1-ksc
7001 a Galantini, Lucianou Sapienza University of Rome4 aut
7102 a Sapienza University of Romeb University of Costa Rica4 org
7730 t Colloids and Surfaces B: Biointerfacesd : Elsevier BVg 185q 185x 0927-7765
8564 u http://dx.doi.org/10.1016/j.colsurfb.2019.110556y FULLTEXT
8564 u https://iris.uniroma1.it/bitstream/11573/1341758/1/Cautela_Bile-salts_2020.pdf
8564 8u https://lup.lub.lu.se/record/8e876198-93d8-46ff-8e67-70e085287ac7
8564 8u https://doi.org/10.1016/j.colsurfb.2019.110556

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