Sökning: WFRF:(Gottfried M)
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Infliximab or cyclo...
Infliximab or cyclosporine as rescue therapy in hospitalized patients with steroid-refractory ulcerative colitis : a retrospective observational study
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- Sjöberg, Mats, 1965- (författare)
- Department of Medicine, Skaraborgs hospital, Lidköping, Sweden
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- Walch, Andrea (författare)
- Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
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- Hellström, Per M., 1954- (författare)
- Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria,Karolinska University Hospital, Solna
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- Gustavsson, Anders, 1964- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Järnerot, Gunnar (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Vogelsang, Harald (författare)
- Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
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- Hertervig, Erik (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Lund University
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- Novacek, Gottfried (författare)
- Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
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- Friis-Liby, Ingalill (författare)
- Department of Medicine, Division of Gastroenterology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Blomquist, Lars (författare)
- Department of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Stockholm, Sweden
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- Angelberger, Sieglinde (författare)
- Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
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- Karlén, Per (författare)
- Karolinska Institutet,Södersjukhuset, Stockholm
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- Granno, Christer (författare)
- Department of Medicine, Division of Gastroenterology, Ryhov Hospital, Jönköping, Sweden
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- Vilien, Mogens (författare)
- Division of Gastroenterology, Hilleroed Hospital, Hilleroed, Denmark
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- Ström, Magnus (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Verbaan, Hans (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital, Malmö
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- Hellström, Per M. (författare)
- Department of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Stockholm, Sweden
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- Dejaco, Clemens (författare)
- Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
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- Magnuson, Anders (författare)
- Clinical epidemiology and biostatistic unit, Örebro University Hospital, Örebro, Sweden
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Reinisch, Walter (författare)
- Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
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- Tysk, Curt, 1949- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University Hospital
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(creator_code:org_t)
- John Wiley & Sons, 2012
- 2012
- Engelska.
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Ingår i: Inflammatory Bowel Diseases. - : John Wiley & Sons. - 1078-0998 .- 1536-4844. ; 18:2, s. 212-218
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Cyclosporine (CsA) or infliximab (IFX) are used as rescue therapies in steroid-refractory, severe attacks of ulcerative colitis (UC). There are no data comparing the efficacy of these two alternatives. Methods: Outcome of rescue therapy was retrospectively studied in two cohorts of patients hospitalized due to steroid-refractory moderate to severe UC: 1) a Swedish-Danish cohort (n 49) treated with a single infusion of IFX; 2) an Austrian cohort (n 43) treated with intravenous CsA. After successful rescue therapy, maintenance immunomodulator treatment was given to 27/33 (82%) of IFX patients and to 31/40 (78%) of CsA patients. Endpoints were colectomy-free survival at 3 and 12 months. Kaplan-Meier and Cox regression models were used to evaluate the association between treatment groups and colectomy. Results: At 15 days, colectomy-free survival in the IFX cohort was 36/49 (73%) versus 41/43 (95%) in the CsA cohort (P = 0.005), at 3 months 33/49 (67%) versus 40/43 (93%) (P = 0.002), and at 12 months 28/49 (57%) versus 33/43 (77%) (P = 0.034). After adjusting for potential confounding factors, Cox regression analysis yielded adjusted hazard ratios for risk of colectomy in IFX-treated patients of 11.2 (95% confidence interval [CI] 2.4-53.1, P = 0.002) at 3 months and of 3.0 (95% CI 1.1-8.2, P = 0.030) at 12 months in comparison with CsA-treated patients. There were no opportunistic infections or mortality. Conclusions: Colectomy frequencies were significantly lower after rescue therapy with CsA than with a single infusion of IFX both at 3 and 12 months' follow-up. The superiority of CsA was seen principally during the first 15 days.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Ulcerative colitis
- cyclosporine
- infliximab
- rescue therapy
- colectomy
- Medicine
- Medicin
- Medicinsk vetenskap
- ulcerative colitis
- cyclosporine
- infliximab
- rescue therapy
- colectomy
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Sjöberg, Mats, 1 ...
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Walch, Andrea
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Hellström, Per M ...
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Gustavsson, Ande ...
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Järnerot, Gunnar
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Vogelsang, Haral ...
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Hertervig, Erik
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Novacek, Gottfri ...
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Friis-Liby, Inga ...
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Blomquist, Lars
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Angelberger, Sie ...
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Karlén, Per
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Granno, Christer
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Vilien, Mogens
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Ström, Magnus
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Verbaan, Hans
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Hellström, Per M ...
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Dejaco, Clemens
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Magnuson, Anders
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Halfvarson, Jona ...
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Reinisch, Walter
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Tysk, Curt, 1949 ...
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