Sökning: WFRF:(Grollier G) > (2015-2019) > Rationale and desig...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05947naa a2200901 4500 | |
001 | oai:lup.lub.lu.se:259b90c6-94ad-4874-bad5-584c73ffa09e | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/74105292 URI |
024 | 7 | a https://doi.org/10.1016/j.ahj.2015.02.0202 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Mewton, Nathan4 aut |
245 | 1 0 | a Rationale and design of the Cyclosporine to ImpRove Clinical oUtcome in ST-elevation myocardial infarction patients (the CIRCUS trial) |
264 | 1 | b Elsevier BV,c 2015 |
520 | a Background Both acute myocardial ischemia and reperfusion contribute to cardiomyocyte death in ST-elevation myocardial infarction (STEMI). The final infarct size is the principal determinant of subsequent clinical outcome in STEMI patients. In a proof-of-concept phase II trial, the administration of cyclosporine prior to primary percutaneous coronary intervention (PPCI) has been associated with a reduction of infarct size in STEMI patients. Methods CIRCUS is an international, prospective, multicenter, randomized, double-blinded, placebo-controlled trial. The study is designed to compare the efficacy and safety of cyclosporine versus placebo, in addition to revascularization by PPCI, in patients presenting with acute anterior myocardial infarction within 12 hours of symptoms onset and initial TIMI flow <= 1 in the culprit left anterior descending coronary artery. Patients are randomized in a 1: 1 fashion to 2.5 mg/kg intravenous infusion of cyclosporine or matching placebo performed in theminutes preceding PCI. The primary efficacy end point of CIRCUS is a composite of 1-year all-cause mortality, rehospitalization for heart failure or heart failure worsening during initial hospitalization, and left ventricular adverse remodeling as determined by sequential transthoracic echochardiography. Secondary outcomes will be tested using a hierarchical sequence of left ventricular (LV) ejection fraction and absolute measurements of LV volumes. The composite of death and rehospitalization for heart failure or heart failure worsening during initial hospitalization will be further assessed at three years after the initial infarction. Results Recruitment lasted from April 2011 to February 2014. The CIRCUS trial has recruited 975 patients with acute anterior myocardial infarction. The 12-months results are expected to be available in 2015. Conclusions The CIRCUS trial is testing the hypothesis that cyclosporine in addition to early revascularization with PPCI compared to placebo in patients with acute anterior myocardial infarction reduces the incidence of death, heart failure and adverse LV remodeling at one-year follow-up. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Cung, Thien T.4 aut |
700 | 1 | a Morel, Olivier4 aut |
700 | 1 | a Cayla, Guillaume4 aut |
700 | 1 | a Bonnefoy-Cudraz, Eric4 aut |
700 | 1 | a Rioufol, Gilles4 aut |
700 | 1 | a Angoulvant, Denis4 aut |
700 | 1 | a Guerin, Patrice4 aut |
700 | 1 | a Elbaz, Meyer4 aut |
700 | 1 | a Delarche, Nicolas4 aut |
700 | 1 | a Coste, Pierre4 aut |
700 | 1 | a Vanzetto, Gerald4 aut |
700 | 1 | a Metge, Marc4 aut |
700 | 1 | a Aupetit, Jean-Francois4 aut |
700 | 1 | a Jouve, Bernard4 aut |
700 | 1 | a Motreff, Pascal4 aut |
700 | 1 | a Tron, Christophe4 aut |
700 | 1 | a Labeque, Jean-Noel4 aut |
700 | 1 | a Steg, Pierre G.4 aut |
700 | 1 | a Cottin, Yves4 aut |
700 | 1 | a Range, Gregoire4 aut |
700 | 1 | a Clerc, Jerome4 aut |
700 | 1 | a Coussement, Patrick4 aut |
700 | 1 | a Prunier, Fabrice4 aut |
700 | 1 | a Moulin, Frederique4 aut |
700 | 1 | a Roth, Olivier4 aut |
700 | 1 | a Belle, Loic4 aut |
700 | 1 | a Dubois, Phillipe4 aut |
700 | 1 | a Barragan, Paul4 aut |
700 | 1 | a Gilard, Martine4 aut |
700 | 1 | a Piot, Christophe4 aut |
700 | 1 | a Colin, Patrice4 aut |
700 | 1 | a Morice, Marie-Claude4 aut |
700 | 1 | a Monassier, Jean-Pierre4 aut |
700 | 1 | a Ider, Omar4 aut |
700 | 1 | a Dubois-Rande, Jean Luc P.4 aut |
700 | 1 | a Unterseeh, Thierry4 aut |
700 | 1 | a Lebreton, Herve4 aut |
700 | 1 | a Beard, Thierry4 aut |
700 | 1 | a Blanchard, Didier4 aut |
700 | 1 | a Grollier, Gilles4 aut |
700 | 1 | a Malquarti, Vincent4 aut |
700 | 1 | a Staat, Patrick4 aut |
700 | 1 | a Sudre, Arnaud4 aut |
700 | 1 | a Hansson, Magnusu Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)expb-mha |
700 | 1 | a Elmer, Eskilu Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)expb-eel |
700 | 1 | a Boussaha, Inesse4 aut |
700 | 1 | a Jossan, Claire4 aut |
700 | 1 | a Torner, Anna4 aut |
700 | 1 | a Claeys, Marc4 aut |
700 | 1 | a Garcia-Dorado, David4 aut |
700 | 1 | a Ovize, Michel4 aut |
710 | 2 | a Klinisk fysiologi, Lundb Sektion V4 org |
773 | 0 | t American Heart Journald : Elsevier BVg 169:6, s. 6-766q 169:6<6-766x 1097-6744x 0002-8703 |
856 | 4 | u http://dx.doi.org/10.1016/j.ahj.2015.02.020y FULLTEXT |
856 | 4 | u https://hal-univ-rennes1.archives-ouvertes.fr/hal-01260554/file/Rationale%20and%20Design%20of%20the%20Cyclosporine.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/7410529 |
856 | 4 8 | u https://doi.org/10.1016/j.ahj.2015.02.020 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.